Altered enzymes in ageing human fibroblasts.

Nature ·Vol. 238 ·No. 5358 ·1972-07-07 ·Pages 26-30

Holliday R, Tarrant GM

Abstract

Diploid human fibroblasts accumulate heat labile enzymes during the final stages of their life-span in culture. The RNA base analogue 5-FU induces premature senescence, which is preceded by the appearance of altered enzyme. These observations support Orgel's "error catastrophe" theory of ageing.

MeSH Terms

Cell Death Cell Line Cellular Senescence/drug effects Enzyme Stability Fibroblasts/cytology,drug effects,enzymology,physiology Fluorouracil/pharmacology Glucosephosphate Dehydrogenase/metabolism Hot Temperature Humans Male Phosphogluconate Dehydrogenase/metabolism Substrate Specificity

Chemicals

Phosphogluconate Dehydrogenase Glucosephosphate Dehydrogenase Fluorouracil

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Holliday R

National Institute for Medical Research, Mill Hill, London NW7 1AA.

Tarrant G M

Article Info

Journal

Nature

Abbr.

Nature

ISSN

0028-0836

DOI

10.1038/238026a0

Published

1972-07-07

Pages

26-30

Language

English

Region

England

NLM ID

0410462

Subset

External Links

PubMed source DOI: 10.1038/238026a0 View journal details

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Altered enzymes in ageing human fibroblasts.

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