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PMID: 9824616 Published · ppublish English Journal Article Review

Role of NF-kappaB in immune and inflammatory responses in the gut.

Gut ·Vol. 43 ·No. 6 ·1998-12-00 ·Pages 856-60

Neurath MF, Becker C, Barbulescu K

Abstract

NF-kappaB is a pleiotropic transcription factor with key functions in the intestinal immune system. NF-kappaB family members control transcriptional activity of various promoters of proinflammatory cytokines, cell surface receptors, transcription factors, and adhesion molecules that are involved in intestinal inflammation. The perpetuated activation of NF-kappaB in patients with active inflammatory bowel disease suggests that regulation of NF-kappaB activity is a very attractive target for therapeutic intervention. Such strategies include antioxidants, proteasome inhibitors, inhibition of NF-kappaB by adenoviral I kappaB alpha expression vectors, and antisense DNA targeting of NF-kappaB. These approaches will hopefully permit the design of new treatment strategies for chronic intestinal inflammation.

MeSH Terms
Animals Humans Inflammation/immunology Intestinal Diseases/immunology Mice Mice, Knockout NF-kappa B/classification,genetics,immunology Signal Transduction Transcription Factors/immunology
Chemicals
NF-kappa B Transcription Factors
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Neurath M F
Laboratory of Immunology, I. Medical Clinic, University of Mainz, Langenbeckstrasse, 55101 Mainz, Germany.
Becker C
Barbulescu K
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Article Info
Journal
Gut
Abbr.
Gut
ISSN
0017-5749
DOI
10.1136/gut.43.6.856
Published
1998-12-00
Pages
856-60
Language
English
Region
England
NLM ID
2985108R
PMCID
PMC1727350
Subset
IM
External Links
PubMed source DOI: 10.1136/gut.43.6.856 PMC Full Text View journal details
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