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PMID: 9811672 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

mmr, a Mycobacterium tuberculosis gene conferring resistance to small cationic dyes and inhibitors.

Journal of bacteriology ·Vol. 180 ·No. 22 ·1998-11-00 ·Pages 6068-71

De Rossi E, Branzoni M, Cantoni R, Milano A, Riccardi G, Ciferri O

Abstract

The mmr gene, cloned from Mycobacterium tuberculosis, was shown to confer to Mycobacterium smegmatis resistance to tetraphenylphosphonium (TPP), erythromycin, ethidium bromide, acriflavine, safranin O, and pyronin Y. The gene appears to code for a protein containing four transmembrane domains. Studies of [3H]TPP intracellular accumulation strongly suggest that the resistance mediated by the Mmr protein involves active extrusion of TPP.

MeSH Terms

Amino Acid Sequence Cloning, Molecular Coloring Agents Drug Resistance, Microbial/genetics Genes, Bacterial Indicators and Reagents Molecular Sequence Data Mycobacterium tuberculosis/genetics Onium Compounds Organophosphorus Compounds R Factors Sequence Analysis, DNA Tritium

Chemicals

Coloring Agents Indicators and Reagents Onium Compounds Organophosphorus Compounds Tritium tetraphenylphosphonium

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

De Rossi E

Department of Genetics and Microbiology, University of Pavia, 27100 Pavia, Italy.

Branzoni M

Cantoni R

Milano A

Riccardi G

Ciferri O

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Article Info

Journal

Journal of bacteriology

Abbr.

J Bacteriol

ISSN

0021-9193

DOI

10.1128/JB.180.22.6068-6071.1998

Published

1998-11-00

Pages

6068-71

Language

English

Region

United States

NLM ID

2985120R

PMCID

PMC107688

Subset

External Links

PubMed source DOI: 10.1128/JB.180.22.6068-6071.1998 PMC Full Text View journal details

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mmr, a Mycobacterium tuberculosis gene conferring resistance to small cationic dyes and inhibitors.

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