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PMID: 9755152 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

DNA damage checkpoint in budding yeast.

The EMBO journal ·Vol. 17 ·No. 19 ·1998-10-01 ·Pages 5525-8

Longhese MP, Foiani M, Muzi-Falconi M, Lucchini G, Plevani P

Abstract

Eukaryotic cells have evolved a network of control mechanisms, known as checkpoints, which coordinate cell-cycle progression in response to internal and external cues. The yeast Saccharomyces cerevisiae has been invaluable in dissecting genetically the DNA damage checkpoint pathway. Recent results on posttranslational modifications and protein-protein interactions of some key factors provide new insights into the architecture of checkpoint protein complexes and their order of function.

MeSH Terms

Cell Cycle/genetics DNA Damage DNA Replication Evolution, Molecular Genes, Fungal Models, Genetic Saccharomyces cerevisiae/cytology,genetics

Authors & Affiliations

5 authors, click to expand affiliations / ORCID

Longhese M P

Dipartimento di Genetica e Biologia dei Microrganismi, Via Celoria 26, 20133 Milano, Italy.

Foiani M

Muzi-Falconi M

Lucchini G

Plevani P

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28 references, click to expand

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Article Info

Journal

The EMBO journal

Abbr.

EMBO J

ISSN

0261-4189

DOI

10.1093/emboj/17.19.5525

Published

1998-10-01

Pages

5525-8

Language

English

Region

England

NLM ID

8208664

PMCID

PMC1170880

Subset

Grants

Telethon · 1018 · Italy

External Links

PubMed source DOI: 10.1093/emboj/17.19.5525 PMC Full Text View journal details

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DNA damage checkpoint in budding yeast.

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