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PMID: 9707586 Published · ppublish English Journal Article

Clustering of non-major histocompatibility complex susceptibility candidate loci in human autoimmune diseases.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 95 ·No. 17 ·1998-08-18 ·Pages 9979-84

Becker KG, Simon RM, Bailey-Wilson JE, Freidlin B, Biddison WE, McFarland HF, Trent JM

Abstract

Human autoimmune diseases are thought to develop through a complex combination of genetic and environmental factors. Genome-wide linkage searches of autoimmune and inflammatory/immune disorders have identified a large number of non-major histocompatibility complex loci that collectively contribute to disease susceptibility. A comparison was made of the linkage results from 23 published autoimmune or immune-mediated disease genome-wide scans. Human diseases included multiple sclerosis, Crohn's disease, familial psoriasis, asthma, and type-I diabetes (IDDM). Experimental animal disease studies included murine experimental autoimmune encephalomyelitis, rat inflammatory arthritis, rat and murine IDDM, histamine sensitization, immunity to exogenous antigens, and murine lupus (systemic lupus erythematosus; SLE). A majority (approximately 65%) of the human positive linkages map nonrandomly into 18 distinct clusters. Overlapping of susceptibility loci occurs between different human immune diseases and by comparing conserved regions with experimental autoimmune/immune disease models. This nonrandom clustering supports a hypothesis that, in some cases, clinically distinct autoimmune diseases may be controlled by a common set of susceptibility genes.

MeSH Terms
Animals Asthma/genetics Autoimmune Diseases/genetics Chromosome Mapping Chromosomes, Human/genetics Crohn Disease/genetics Diabetes Mellitus, Type 1/genetics Disease Models, Animal Female Genetic Linkage Genetic Markers Humans Male Mice Multigene Family Multiple Sclerosis/genetics Psoriasis/genetics Rats
Chemicals
Genetic Markers
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Becker K G
Cancer Genetics Branch, National Human Genome Research Institute, National Institutes of Health, Bethesda, MD 20892, USA. kbecker@nhgri.nih.gov
Simon R M
Bailey-Wilson J E
Freidlin B
Biddison W E
McFarland H F
Trent J M
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.95.17.9979
Email
kbecker@nhgri.nih.gov
Published
1998-08-18
Pages
9979-84
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC21447
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.95.17.9979 PMC Full Text View journal details
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