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PMID: 96738 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Characterization of a small plasmid determining resistance to erythromycin, lincomycin, and vernamycin Balpha in a strain of Streptococcus sanguis isolated from dental plaque.

Antimicrobial agents and chemotherapy ·Vol. 13 ·No. 5 ·1978-05-00 ·Pages 884-7

Yagi Y, McLellan TS, Frez WA, Clewell DB

Abstract

A plasmid determining resistance to erythromycin (inducible), lincomycin, and vernamycin B(alpha) was isolated from a strain of Streptococcus sanguis isolated from dental plaque of a patient who had been on erythromycin therapy for an extended period of time. The plasmid, designated pAM77, had a molecular weight of 4.5 x 10(6) and was present to the extent of one to two copies per bacterial chromosome. The plasmid could transform S. sanguis strain Challis.

MeSH Terms

Anti-Bacterial Agents/pharmacology DNA, Bacterial/analysis Dental Plaque/microbiology Erythromycin/pharmacology Humans Lincomycin/pharmacology R Factors Streptococcus sanguis/analysis,drug effects,isolation & purification Virginiamycin/pharmacology

Chemicals

Anti-Bacterial Agents DNA, Bacterial Virginiamycin Erythromycin Lincomycin

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Yagi Y

McLellan T S

Frez W A

Clewell D B

References (26)

26 references, click to expand

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Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.13.5.884

Published

1978-05-00

Pages

884-7

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC352349

Subset

External Links

PubMed source DOI: 10.1128/AAC.13.5.884 PMC Full Text View journal details

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Characterization of a small plasmid determining resistance to erythromycin, lincomycin, and vernamycin Balpha in a strain of Streptococcus sanguis isolated from dental plaque.

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