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PMID: 810482 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Transmissible toxin (hemolysin) plasmid in Streptococcus faecalis and its mobilization of a noninfectious drug resistance plasmid.

Journal of bacteriology ·Vol. 124 ·No. 2 ·1975-11-00 ·Pages 784-90

Dunny GM, Clewell DB

Abstract

Streptococcus faecalis strain DS-5 has been shown previously to contain three plasmids, pAMalpha1, pAMbeta1, and pAMgamma1. Mixed incubation of DS-5 with strain JH2-2, a plasmid-free S. faecalis recipient, results in the transfer of pAMalpha1 (which determines resistance to tetracycline) and/or pAMgamma1. Analyses of recipients carrying various combinations of these plasmids have revealed the pAMgamma1 codes for toxin (hemolysin) production and two bacteriocin activities. JH2-2 strains carrying both pAMalpha1 and pAMgamma1, or pAMgamma1 only, can donate their plasmids to other recipients, whereas strains carrying only pAMalpha1 cannot serve as donors. This indicates that pAMgamma1 actually mobilizes the otherwise nontransferable pAMalpha1.

MeSH Terms
Bacteriocins/biosynthesis Conjugation, Genetic DNA, Bacterial/analysis Drug Resistance, Microbial Enterococcus faecalis/analysis,drug effects,metabolism Extrachromosomal Inheritance Hemolysin Proteins/biosynthesis Plasmids Tetracycline/pharmacology
Chemicals
Bacteriocins DNA, Bacterial Hemolysin Proteins Tetracycline
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Dunny G M
Clewell D B
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19 references, click to expand
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/jb.124.2.784-790.1975
Published
1975-11-00
Pages
784-90
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC235968
Subset
IM
External Links
PubMed source DOI: 10.1128/jb.124.2.784-790.1975 PMC Full Text View journal details
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