Familial C/D translocation t(9;13)(9p23.13q21) in a male associated with recurrent abortion.

Human genetics ·Vol. 33 ·No. 3 ·1976-08-30 ·Pages 223-30

Singh-Kahlon D, Serra A

Abstract

A familial reciprocal translocation, established by R-banding as t(9;13) (9p23;13q21), is described in a phenotypically normal male carrier, whose father is also a balanced carrier and wife had four consecutive spontaneous abortions. The role of translocation in reproductive failure through production of chromosomally unbalanced gametes or by impairment of the spermatogenesis is briefly discussed.

MeSH Terms

Abortion, Habitual/genetics Adult Chromosome Aberrations Chromosomes, Human, 13-15 Chromosomes, Human, 6-12 and X Female Humans Male Pregnancy Translocation, Genetic

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Singh-Kahlon D

Serra A

References (20)

20 references, click to expand

A simple R banding technic.
Am J Hum Genet. 1975 Jan;27(1):110-7 PMID: 50737
A case of partial 14 trisomy 47,XY,(14q-)+ and translocation t(9p+;14q-) in mother and brother.
J Med Genet. 1972 Sep;9(3):367-73 PMID: 5079109
[A new technic of analysis of the human karyotype].
C R Acad Sci Hebd Seances Acad Sci D. 1971 May 17;272(20):2638-40 PMID: 4104656
Prenatal cytogenetic analysis of women with high risk for genetic disorders.
J Hered. 1974 Jul-Aug;65(4):209-12 PMID: 4278231
A family with balanced D1-Cs-translocation carriers and unbalanced offspring.
Humangenetik. 1964;1(2):197-200 PMID: 5869480
[6-12 13-15 translocation and partial 6-12 trisomy (probably 10)].
Ann Genet. 1965;8(1):16-20 PMID: 5294576
Translocation +(7p+; Bq-) associated with recurrent abortion.
Humangenetik. 1975 May 26;28(1):83-6 PMID: 1171079
Partial trisomy 13: karyotype 46,XY,-6, plus t(13q,6q).
Humangenetik. 1974 Jan 22;21(1):47-54 PMID: 4837512
Inherited translocations in two families (t(14q+;10q-) and t(13q-;21q+)).
Humangenetik. 1973 Sep 20;19(3):215-26 PMID: 4763926
[Chromosome studies in couples with repeated abortions].
Arch Gynakol. 1972;213(2):110-8 PMID: 4678743
Karyotype, meiosis and spermatogenesis in a sample of men attending an infertility clinic.
Monogr Hum Genet. 1966;2:1-93 PMID: 6015462
Possible partial trisomy of a chromosome of group 6-X-12 and familial translocation heterozygosity in a child with congenital abnormalities.
Dev Med Child Neurol. 1967 Jun;9(3):313-8 PMID: 6035579
Cytogenetics of habitual abortion.
Obstet Gynecol. 1968 Oct;32(4):548-55 PMID: 5742467
The use of proteolytic enzymes for the mapping of structural rearrangements in the chromosomes of man.
Chromosoma. 1972;36(2):204-10 PMID: 5016007
Translocation heterozygosity and associated subfertility in man.
Cytogenetics. 1972;11(6):516-33 PMID: 4658180
[The role of parental translocations in cases of repeated miscarriages].
Rev Fr Gynecol Obstet. 1973 Nov;68(11):655-60 PMID: 17474223
A familial 10/13 translocation: partial trisomy C in an infant associated with familial 10/13 translocation.
Clin Genet. 1974;6(5):335-40 PMID: 4434650
Genetic activity of sex chromosomes in germinal cells.
Philos Trans R Soc Lond B Biol Sci. 1970 Aug 6;259(828):53-5 PMID: 4399068
Cytogenetics of habitual abortion. A review.
Obstet Gynecol Surv. 1974 May;29(5):290-310 PMID: 4615284
Transmission of a translocation t(Cp+; Dq-) through three generations; including an example of probable trisomy for the short arm of the C group chromosome No. 9.
Ann Genet. 1969 Mar;12(1):15-27 PMID: 5306708

Article Info

Journal

Human genetics

Abbr.

Hum Genet

ISSN

0340-6717

DOI

10.1007/BF00286846

Published

1976-08-30

Pages

223-30

Language

English

Region

Germany

NLM ID

7613873

Subset

External Links

PubMed source DOI: 10.1007/BF00286846 View journal details

Analysis Services

Familial C/D translocation t(9;13)(9p23.13q21) in a male associated with recurrent abortion.

Contact

WeChat Official Account