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PMID: 9649421 Published · ppublish English Journal Article Review

Transducing Hedgehog: the story so far.

The EMBO journal ·Vol. 17 ·No. 13 ·1998-07-01 ·Pages 3505-11

Ingham PW

Abstract

The secreted proteins of the Hedgehog family have been implicated in many different processes in vertebrate development including cartilage differentiation, myotome and sclerotome specification, hair follicle development, limb morphogenesis and the specification of different neuronal cell types. In addition, the aberrant activation of the Hedgehog pathway has been identified as the likely cause of a number of tumours in humans including basal cell carcinomas (BCCs) and primitive neurectodermal tumours (PNETs). Elucidating the mechanisms by which Hedgehog signals are transduced will thus have widespread implications for our understanding of both normal development and disease.

MeSH Terms
Animals Drosophila Proteins Hedgehog Proteins Humans Insect Proteins/genetics,metabolism Membrane Proteins/metabolism Patched Receptors Proteins/genetics,metabolism Receptors, Cell Surface/metabolism Receptors, G-Protein-Coupled Signal Transduction Smoothened Receptor Trans-Activators
Chemicals
Drosophila Proteins Hedgehog Proteins Insect Proteins Membrane Proteins Patched Receptors Proteins Receptors, Cell Surface Receptors, G-Protein-Coupled SMO protein, human Smoothened Receptor Trans-Activators ptc protein, Drosophila smo protein, Drosophila hh protein, Drosophila
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Ingham P W
Developmental Genetics Programme, The Krebs Institute, University of Sheffield, Sheffield S10 2TN, UK.
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Article Info
Journal
The EMBO journal
Abbr.
EMBO J
ISSN
0261-4189
DOI
10.1093/emboj/17.13.3505
Published
1998-07-01
Pages
3505-11
Language
English
Region
England
NLM ID
8208664
PMCID
PMC1170687
Subset
IM
External Links
PubMed source DOI: 10.1093/emboj/17.13.3505 PMC Full Text View journal details
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