Hedgehog and patched gene expression in adult ocular tissues.

FEBS letters ·Vol. 410 ·No. 2-3 ·1997-06-30 ·Pages 485-9

Takabatake T, Ogawa M, Takahashi TC, Mizuno M, Okamoto M, Takeshima K

Abstract

We analysed the expression of members of the hh gene family in adult ocular tissues of newt, frog and mouse by RT-PCR method. Shh displayed restricted expression in the neural retina that was conserved in each species analyzed. X-bhh, X-chh and mouse Ihh were detected in the iris and in the retinal pigment epithelium, while mouse Dhh was detected additionally in the neural retina and faintly in the cornea. We also found that two types of ptc genes, potential hh targets and receptors, were expressed in these tissues, suggesting the presence of active hh signalling there.

MeSH Terms

Amino Acid Sequence Animals Eye/embryology,metabolism Gene Expression Gene Expression Regulation, Developmental Hedgehog Proteins Intracellular Signaling Peptides and Proteins Membrane Proteins/genetics Mice Mice, Inbred BALB C Molecular Sequence Data Patched Receptors Patched-1 Receptor Proteins/genetics Receptors, Cell Surface Salamandridae Trans-Activators Up-Regulation Xenopus Proteins Xenopus laevis

Chemicals

Hedgehog Proteins IHH protein, Xenopus Intracellular Signaling Peptides and Proteins Membrane Proteins Patched Receptors Patched-1 Receptor Proteins Ptch1 protein, mouse Receptors, Cell Surface Trans-Activators Xenopus Proteins

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Takabatake T

Radioisotope Research Center, Nagoya University, Japan.

Ogawa M

Takahashi T C

Mizuno M

Okamoto M

Takeshima K

Article Info

Journal

FEBS letters

Abbr.

FEBS Lett

ISSN

0014-5793

DOI

10.1016/s0014-5793(97)00645-5

Published

1997-06-30

Pages

485-9

Language

English

Region

England

NLM ID

0155157

Subset

Databases

GENBANK

AB000846, AB000848, AB010833

External Links

PubMed source DOI: 10.1016/s0014-5793(97)00645-5 View journal details

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Hedgehog and patched gene expression in adult ocular tissues.

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