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PMID: 9641507 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Systemic sclerosis stimulates angiogenesis in the chick embryo chorioallantoic membrane.

Clinical rheumatology ·Vol. 17 ·No. 2 ·1998-00-00 ·Pages 115-20

Ribatti D, Cantatore FP, Vacca A, D'Amore M, Ria R, Roncali L, Pipitone V

Abstract

Skin biopsies from patients with systemic sclerosis (SSc) were investigated for their angiogenic activity by using the chick embryo chorioallantoic membrane (CAM) assay. Ten samples of SSc and 10 of normal skin from age- and sex-matched subjects were grafted onto the CAM, and the angiogenic response in pathological and control implants was assessed on histological sections by a planimetric point-count method 4 days after grafting. The vascular counts in the area underlying the SSc were significantly higher than those of normal skin and a dense mononuclear cell infiltrate was detectable around the blood vessels in pathological specimens. These results suggest that SSc may promote angiogenesis, perhaps leading to the release of several angiogenic factors. Moreover, the role played in the angiogenic response by the inflammatory cells forming the cellular infiltrate is suggested by this study.

MeSH Terms
Adult Allantois/blood supply,immunology Animals Chick Embryo Chorion/blood supply,immunology Female Humans Leukocytes, Mononuclear/cytology Male Middle Aged Neovascularization, Pathologic/immunology,physiopathology Scleroderma, Systemic/immunology,physiopathology
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Ribatti D
Institute of Human Anatomy, Histology and Embryology, University of Bari Medical School, Italy. ribatti@anatomia.uniba.it
Cantatore F P
Vacca A
D'Amore M
Ria R
Roncali L
Pipitone V
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Article Info
Journal
Clinical rheumatology
Abbr.
Clin Rheumatol
ISSN
0770-3198
DOI
10.1007/BF01452256
Email
ribatti@anatomia.uniba.it
Published
1998-00-00
Pages
115-20
Language
English
Region
Germany
NLM ID
8211469
Subset
IM
External Links
PubMed source DOI: 10.1007/BF01452256 View journal details
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