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PMID: 7531623 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Transformation of fibroblasts into endothelial cells during angiogenesis.

Cell and tissue research ·Vol. 278 ·No. 3 ·1994-12-00 ·Pages 625-8

Kon K, Fujiwara T

Abstract

Light- and electron-microscopic autoradiography have been used to study fibroblast transformation into endothelial cells in the formation of new blood vessels during wound healing in rabbit ear chambers. When cultured fibroblasts labeled with tritium thymidine were transplanted autologously into the chambers, newly formed blood vessels contained endothelial cells labeled with tritium thymidine. This result suggests that fibroblasts play a pivotal role in angiogenesis, as progenitors of endothelial cells in newly formed blood vessels.

MeSH Terms
Animals Autoradiography Cell Differentiation Cell Transplantation Cells, Cultured Ear/blood supply Endothelium, Vascular/cytology,ultrastructure Fibroblasts/cytology,transplantation Microscopy, Electron Neovascularization, Pathologic Rabbits Wound Healing
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Kon K
Department of Medical Laboratory Technology, Ehime College of Health Science, Japan.
Fujiwara T
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Article Info
Journal
Cell and tissue research
Abbr.
Cell Tissue Res
ISSN
0302-766X
DOI
10.1007/BF00331383
Published
1994-12-00
Pages
625-8
Language
English
Region
Germany
NLM ID
0417625
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00331383 View journal details
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