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PMID: 9564564 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Review

Structures of Toxoplasma gondii tachyzoites, bradyzoites, and sporozoites and biology and development of tissue cysts.

Clinical microbiology reviews ·Vol. 11 ·No. 2 ·1998-04-00 ·Pages 267-99

Dubey JP, Lindsay DS, Speer CA

Abstract

Infections by the protozoan parasite Toxoplasma gondii are widely prevalent world-wide in animals and humans. This paper reviews the life cycle; the structure of tachyzoites, bradyzoites, oocysts, sporocysts, sporozoites and enteroepithelial stages of T. gondii; and the mode of penetration of T. gondii. The review provides a detailed account of the biology of tissue cysts and bradyzoites including in vivo and in vitro development, methods of separation from host tissue, tissue cyst rupture, and relapse. The mechanism of in vivo and in vitro stage conversion from sporozoites to tachyzoites to bradyzoites and from bradyzoites to tachyzoites to bradyzoites is also discussed.

MeSH Terms
Animals Cells, Cultured Host-Parasite Interactions Humans Immunohistochemistry Life Cycle Stages Microscopy, Electron Toxoplasma/growth & development,pathogenicity,ultrastructure Toxoplasmosis/parasitology Toxoplasmosis, Animal/parasitology
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Dubey J P
Parasite Biology and Epidemiology Laboratory, USDA Agricultural Research Service, Beltsville, Maryland 20705-2350, USA. JDUBEY@GGPL.ARSUSDA.GOV
Lindsay D S
Speer C A
References (165)
165 references, click to expand
  1. Feline toxoplasmosis from acutely infected mice and the development of Toxoplasma cysts.
    J Protozool. 1976 Nov;23(4):537-46 PMID: 1003342
  2. Immunosuppression and toxoplasmic encephalitis: clinical and experimental aspects.
    Hum Pathol. 1975 Jan;6(1):97-111 PMID: 1110086
  3. The ultrastructural development of the macrogamete and formation of the oocyst wall of Toxoplasma gondii.
    Acta Pathol Microbiol Scand B. 1975 Oct;83(5):491-505 PMID: 1180061
  4. Review: Toxoplasma gondii cellular invasion.
    Parassitologia. 1992 Dec;34(1-3):31-43 PMID: 1339976
  5. Simultaneous depletion of CD4+ and CD8+ T lymphocytes is required to reactivate chronic infection with Toxoplasma gondii.
    J Immunol. 1992 Jul 1;149(1):175-80 PMID: 1351500
  6. Virulent strains of Toxoplasma gondii comprise a single clonal lineage.
    Nature. 1992 Sep 3;359(6390):82-5 PMID: 1355855
  7. Observations on the development and nature of pseudocysts and cysts of Toxoplasma gondii.
    Trans R Soc Trop Med Hyg. 1958 Sep;52(5):396-407 PMID: 13592878
  8. A rational approach to the treatment of toxoplasmic uveitis.
    Trans Ophthalmol Soc U K. 1958;78:109-21 PMID: 13635727
  9. Morphology and culture of Toxoplasma.
    Arch Ophthalmol. 1960 Nov;64:655-67 PMID: 13715141
  10. Identification of Toxoplasma gondii bradyzoite-specific monoclonal antibodies.
    J Infect Dis. 1992 Jul;166(1):213-5 PMID: 1376757
  11. The prevalence of toxoplasmosis in New Zealand sheep and cattle.
    Am J Vet Res. 1963 Jul;24:673-5 PMID: 13964314
  12. Electron microscope study of Toxoplasma cysts in mouse brain.
    J Protozool. 1962 May;9:235-42 PMID: 14004896
  13. Localization of a Toxoplasma gondii rhoptry protein by immunoelectron microscopy during and after host cell penetration.
    J Protozool. 1992 Jul-Aug;39(4):526-30 PMID: 1403988
  14. MORPHOLOGICAL STUDIES ON THE DEVELOPMENT OF THE TOXOPLASMA CYST.
    Am J Trop Med Hyg. 1963 May;12:321-33 PMID: 14044743
  15. The resistance of the encysted form of Toxoplasma gondii.
    J Parasitol. 1960 Feb;46:11-21 PMID: 14406370
  16. Multiplication of three strains of Toxoplasma gondii in tissue culture.
    J Parasitol. 1962 Jun;48:358-61 PMID: 14454443
  17. Observations on the nature and transmission of toxoplasma in the light of its wide host and geographical range.
    Surv Ophthalmol. 1961 Dec;6:721-58 PMID: 14461620
  18. Invasion of vertebrate cells by Toxoplasma gondii.
    Trends Cell Biol. 1995 Mar;5(3):129-32 PMID: 14732169
  19. Speculation on possible life cycles for the clonal lineages in the genus toxoplasma.
    Parasitol Today. 1997 Oct;13(10):393-7 PMID: 15275153
  20. Developmental differentiation between tachyzoites and bradyzoites of Toxoplasma gondii.
    Parasitol Today. 1996 Jan;12(1):30-3 PMID: 15275305
  21. The in vitro model of tissue cyst formation in Toxoplasma gondii.
    Parasitol Today. 1994 Jul;10(7):281-5 PMID: 15275448
  22. Attachment and invasion of host cells by Toxoplasma gondii.
    Parasitol Today. 1994 May;10(5):184-8 PMID: 15275469
  23. Toxoplasma gondii: differentiation and death of bradyzoites.
    Parasitol Res. 1992;78(1):1-9 PMID: 1584739
  24. Evaluation of the effect of drugs on the cyst form of Toxoplasma gondii.
    J Infect Dis. 1991 Jul;164(1):170-1 PMID: 1647421
  25. Characterization of bradyzoite-specific antigens of Toxoplasma gondii.
    Infect Immun. 1991 Oct;59(10):3750-3 PMID: 1894373
  26. Examination of tissue cyst formation by Toxoplasma gondii in cell cultures using bradyzoites, tachyzoites, and sporozoites.
    J Parasitol. 1991 Feb;77(1):126-32 PMID: 1992083
  27. Toxoplasma gondii: membrane structure differences between zoites demonstrated by freeze fracture analysis.
    Exp Parasitol. 1991 Jan;72(1):99-102 PMID: 1993468
  28. Experimental toxoplasmosis and vaccine tests in Aotus monkeys.
    Am J Trop Med Hyg. 1991 Apr;44(4):382-9 PMID: 2042705
  29. Class I MHC genes and CD8+ T cells determine cyst number in Toxoplasma gondii infection.
    J Immunol. 1990 Nov 15;145(10):3438-41 PMID: 2121825
  30. Exocytosis of Toxoplasma gondii dense granules into the parasitophorous vacuole after host cell invasion.
    Parasitol Res. 1990;76(7):559-62 PMID: 2217114
  31. Neuropathology and host-parasite relationship of acute experimental toxoplasmosis of the blue fox (Alopex lagopus).
    Vet Pathol. 1990 Nov;27(6):381-90 PMID: 2278126
  32. Toxoplasma gondii: antigenic differences between endozoites and cystozoites defined by monoclonal antibodies.
    Parasitol Res. 1989;75(3):189-93 PMID: 2469081
  33. Importance of endogenous IFN-gamma for prevention of toxoplasmic encephalitis in mice.
    J Immunol. 1989 Sep 15;143(6):2045-50 PMID: 2506275
  34. [Toxoplasma gondii: ultrastructural study of cystic formations observed in human fibroblast culture].
    Ann Parasitol Hum Comp. 1989;64(6):403-11 PMID: 2624375
  35. Tissue cyst rupture in mice chronically infected with Toxoplasma gondii. An immunocytochemical and ultrastructural study.
    Parasitol Res. 1989;75(8):599-603 PMID: 2771928
  36. Oocyst-induced Toxoplasma gondii infections in cats.
    J Parasitol. 1989 Oct;75(5):750-5 PMID: 2795377
  37. Genetic regulation of early survival and cyst number after peroral Toxoplasma gondii infection of A x B/B x A recombinant inbred and B10 congenic mice.
    J Immunol. 1989 Nov 1;143(9):3031-4 PMID: 2809214
  38. Phagosome acidification blocked by intracellular Toxoplasma gondii.
    Nature. 1985 May 30-Jun 5;315(6018):416-9 PMID: 2860567
  39. Identification of stage-specific antigens of Toxoplasma gondii.
    Infect Immun. 1989 Mar;57(3):668-72 PMID: 2917778
  40. In vitro cultivation of Toxoplasma gondii cysts in astrocytes in the presence of gamma interferon.
    Infect Immun. 1986 Jan;51(1):147-56 PMID: 3079728
  41. The host-parasite relationship of Toxoplasma gondii in the brains of chronically infected mice.
    Virchows Arch A Pathol Anat Histopathol. 1987;411(1):39-43 PMID: 3107207
  42. Interferon-gamma: the major mediator of resistance against Toxoplasma gondii.
    Science. 1988 Apr 22;240(4851):516-8 PMID: 3128869
  43. Resistance to avirulent Toxoplasma gondii in normal and vaccinated rats.
    APMIS. 1988 Sep;96(9):820-4 PMID: 3166808
  44. Host-parasite relationship in the brains of mice with congenital toxoplasmosis.
    J Pathol. 1988 Nov;156(3):255-61 PMID: 3204455
  45. Long-term persistence of Toxoplasma gondii in tissues of pigs inoculated with T gondii oocysts and effect of freezing on viability of tissue cysts in pork.
    Am J Vet Res. 1988 Jun;49(6):910-3 PMID: 3400928
  46. An ultrastructural study of the early development and tissue cyst formation of Toxoplasma gondii in the brains of mice.
    Parasitol Res. 1987;73(6):483-91 PMID: 3422976
  47. Toxoplasma modifies macrophage phagosomes by secretion of a vesicular network rich in surface proteins.
    J Cell Biol. 1986 Sep;103(3):867-74 PMID: 3528173
  48. Cyst rupture as a pathogenic mechanism of toxoplasmic encephalitis.
    Am J Trop Med Hyg. 1987 May;36(3):517-22 PMID: 3578650
  49. Secretion by Toxoplasma gondii of an antigen that appears to become associated with the parasitophorous vacuole membrane upon invasion of the host cell.
    J Cell Sci. 1987 Sep;88 ( Pt 2):231-9 PMID: 3693424
  50. How does Toxoplasma gondii enter host cells?
    Rev Infect Dis. 1985 Jul-Aug;7(4):449-57 PMID: 3898305
  51. Persistence of encysted Toxoplasma gondii in tissues of equids fed oocysts.
    Am J Vet Res. 1985 Aug;46(8):1753-4 PMID: 4037503
  52. [Demonstration and structure of the microtubular system in Toxoplasma gondii].
    C R Acad Sci Hebd Seances Acad Sci D. 1972 Dec 18;275(25):2899-901 PMID: 4120270
  53. Toxoplasma gondii cysts in cell culture: new biologic evidence.
    J Parasitol. 1977 Dec;63(6):1121-4 PMID: 412941
  54. Adoptive immunity to intracellular infection.
    J Immunol. 1967 Jun;98(6):1309-19 PMID: 4290806
  55. Binary fission as a mode of reproduction of Toxoplasma gondii, RH strain. An electron microscope study.
    Boll Ist Sieroter Milan. 1974;53(2):336-41 PMID: 4425572
  56. Cyst formation by Toxoplasma gondii (RH strain) in vitro. The role of immunologic mechanisms.
    Arch Ophthalmol. 1974 Dec;92(6):496-500 PMID: 4433269
  57. Ultrastructural study of early stages of asexual multiplication and microgametogony of Toxoplasma gondii in the small intestine of the cat.
    Acta Pathol Microbiol Scand B Microbiol Immunol. 1974 Apr;82(2):167-81 PMID: 4528099
  58. A comparative electron microscopic study of the morphology of Toxoplasma gondii by freeze-etch replication and thin sectioning technic.
    J Protozool. 1974 Nov;21(5):710-4 PMID: 4615146
  59. The life cycle of virulent toxoplasma in cell cultures.
    Aust J Exp Biol Med Sci. 1969 Aug;47(4):505-12 PMID: 4898623
  60. Toxoplasma gondii in cats: fecal stages identified as coccidian oocysts.
    Science. 1970 Feb 6;167(3919):893-6 PMID: 4903651
  61. Pursuing toxoplasma.
    J Infect Dis. 1970 Dec;122(6):553-9 PMID: 4922985
  62. Destruction of Toxoplasma gondii by HC1 solution.
    Acta Pathol Microbiol Scand B. 1979 Aug;87(4):217-20 PMID: 495099
  63. Ultrastructural studies on the sporulation of oocysts of Toxoplasma gondii. III. Formation of the sporozoites within the sporocysts.
    Acta Pathol Microbiol Scand B. 1979 Aug;87(4):253-60 PMID: 495102
  64. [Further observations on the asexual reproduction of Toxoplasma gondii and considerations on the concept of endogenesis].
    C R Acad Sci Hebd Seances Acad Sci D. 1970 Dec 9;271(23):2123-6 PMID: 4993798
  65. Cyst-induced toxoplasmosis in cats.
    J Protozool. 1972 Feb;19(1):155-77 PMID: 5008846
  66. An ultrastructural study on the excystation of the sporozoites of Toxoplasma gondii.
    Acta Pathol Microbiol Scand B. 1979 Oct;87(5):277-83 PMID: 525353
  67. [Endopolygeny in Toxoplasma gondii].
    Z Parasitenkd. 1971;36(2):122-30 PMID: 5555447
  68. The fine structure and reproduction of Toxoplasma gondii.
    J Parasitol. 1968 Apr;54(2):209-26 PMID: 5647101
  69. Ultrastructural studies on the sporulation of oocysts of Toxoplasma gondii. I. Development of the zygote and formation of the sporoblasts.
    Acta Pathol Microbiol Scand B. 1979 Jun;87B(3):171-81 PMID: 573045
  70. Ultrastructural studies on the sporulation of oocysts of Toxoplasma gondii. II. Formation of the sporocyst and structure of the sporocyst wall.
    Acta Pathol Microbiol Scand B. 1979 Jun;87B(3):183-90 PMID: 573046
  71. Experimental toxoplasmosis: effects of suppression of the immune response of mice by cortisone and splenectomy.
    Keio J Med. 1966 Mar;15(1):1-10 PMID: 5933105
  72. Separation of Isospora (Toxoplasma) gondii cysts and cystozoites from mouse brain tissue by continuous density-gradient centrifugation.
    Parasitology. 1981 Aug;83(Pt 1):103-8 PMID: 6267543
  73. Scanning electron microscopy of Toxoplasma gondii: parasite torsion and host-cell responses during invasion.
    J Protozool. 1984 May;31(2):288-92 PMID: 6470987
  74. Transmission of toxoplasmosis via milk from lactating mice.
    Acta Pathol Microbiol Immunol Scand B. 1984 Jun;92(3):175-6 PMID: 6485808
  75. Persistence of encysted Toxoplasma gondii in tissues of pigs fed oocysts.
    Am J Vet Res. 1984 Oct;45(10):1941-3 PMID: 6497091
  76. Experimental infection of a bison with Toxoplasma gondii oocysts.
    J Wildl Dis. 1983 Apr;19(2):148-9 PMID: 6684185
  77. Distribution of cysts and tachyzoites in calves and pregnant cows inoculated with Toxoplasma gondii oocysts.
    Vet Parasitol. 1983 Oct;13(3):199-211 PMID: 6686377
  78. Ultrastructural comparison of cysts and zoites of Toxoplasma gondii, Sarcocystis muris, and Hammondia hammondi in skeletal muscle of mice.
    J Parasitol. 1980 Feb;66(1):59-67 PMID: 6767834
  79. Quantitative survival of Toxoplasma gondii tachyzoites and bradyzoites in pepsin and in trypsin solutions.
    Am J Vet Res. 1981 Jan;42(1):128-30 PMID: 6784616
  80. Simple technique for the direct isolation of toxoplasma tissue cysts from fetal ovine brain.
    Vet Rec. 1983 Jan 29;112(5):98-100 PMID: 6829161
  81. Secretion from the rhoptries of Toxoplasma gondii during host-cell invasion.
    J Ultrastruct Res. 1983 Apr;83(1):85-98 PMID: 6854716
  82. Ultrastructural localization of basic proteins on the conoid, rhoptries and micronemes of Toxoplasma gondii.
    Z Parasitenkd. 1978 Jul 4;56(2):123-9 PMID: 695824
  83. Repeat transplacental transfer of Toxoplasma gondii in dairy goats.
    J Am Vet Med Assoc. 1982 May 15;180(10):1220-1 PMID: 7085441
  84. Observations on the ultrastructure of the sporocyst and the initiation of sporozoite formation in Toxoplasma gondii.
    Acta Pathol Microbiol Scand B. 1978 Jun;86B(3):165-7 PMID: 716917
  85. Induced Toxoplasma gondii, Toxocara canis, and Isospora canis infections in coyotes.
    J Am Vet Med Assoc. 1982 Dec 1;181(11):1268-9 PMID: 7174440
  86. Mechanism of entry of Toxoplasma gondii into vertebrate cells.
    J Submicrosc Cytol. 1982 Jul;14(3):471-82 PMID: 7175984
  87. Penetration of mouse peritoneal macrophages by the protozoon Toxoplasma gondii. New evidence for active invasion and phagocytosis.
    Lab Invest. 1981 Apr;44(4):324-35 PMID: 7206629
  88. Comparison of the development of avirulent and virulent strains of Toxoplasma gondii in the peritoneal exudate of mice.
    Ann Trop Med Parasitol. 1981 Oct;75(5):539-46 PMID: 7316579
  89. Ultrastructure of excystment of Toxoplasma gondii oocysts.
    J Protozool. 1978 Nov;25(4):438-43 PMID: 739410
  90. Experimental toxoplasmosis in elk (Cervus canadensis).
    Am J Vet Res. 1980 May;41(5):792-3 PMID: 7406299
  91. Toxoplasma gondii: identification and characterization of a cyst molecule.
    Exp Parasitol. 1995 Mar;80(2):228-33 PMID: 7534723
  92. Definitive identification of a gene that confers resistance against Toxoplasma cyst burden and encephalitis.
    Immunology. 1995 Jul;85(3):419-28 PMID: 7558130
  93. Toxoplasma gondii comprises three clonal lineages: correlation of parasite genotype with human disease.
    J Infect Dis. 1995 Dec;172(6):1561-6 PMID: 7594717
  94. Regulated secretion of multi-lamellar vesicles leads to formation of a tubulo-vesicular network in host-cell vacuoles occupied by Toxoplasma gondii.
    J Cell Sci. 1995 Apr;108 ( Pt 4):1669-77 PMID: 7615684
  95. Invasion of Toxoplasma gondii occurs by active penetration of the host cell.
    J Cell Sci. 1995 Jun;108 ( Pt 6):2457-64 PMID: 7673360
  96. Toxoplasma gondii: kinetics of bradyzoite-tachyzoite interconversion in vitro.
    Exp Parasitol. 1993 May;76(3):259-64 PMID: 7684705
  97. Molecular tools for genetic dissection of the protozoan parasite Toxoplasma gondii.
    Methods Cell Biol. 1994;45:27-63 PMID: 7707991
  98. A cell culture system for study of the development of Toxoplasma gondii bradyzoites.
    J Eukaryot Microbiol. 1995 Mar-Apr;42(2):150-7 PMID: 7757057
  99. Ultrastructural effects of diclazuril against Toxoplasma gondii and investigation of a diclazuril-resistant mutant.
    J Parasitol. 1995 Jun;81(3):459-66 PMID: 7776135
  100. Toxoplasma gondii: strain- and host cell-dependent induction of stage differentiation.
    J Eukaryot Microbiol. 1994 Sep-Oct;41(5):10S-11S PMID: 7804194
  101. Tissue cyst formation of Toxoplasma gondii T-263 in cell culture.
    J Eukaryot Microbiol. 1994 Sep-Oct;41(5):17S PMID: 7804222
  102. Development of bradyzoites of Toxoplasma gondii in vitro.
    J Eukaryot Microbiol. 1994 Sep-Oct;41(5):18S PMID: 7804223
  103. A morphological study of chronic cerebral toxoplasmosis in mice: comparison of four different strains of Toxoplasma gondii.
    Parasitol Res. 1994;80(6):493-501 PMID: 7808999
  104. A spectrum in the pathology of toxoplasmosis in patients with acquired immunodeficiency syndrome.
    Arch Pathol Lab Med. 1995 Mar;119(3):214-24 PMID: 7887774
  105. Host resistance to Toxoplasma gondii: model for studying the selective induction of cell-mediated immunity by intracellular parasites.
    Infect Agents Dis. 1993 Jun;2(3):139-49 PMID: 7909708
  106. The Toxoplasma gondii rhoptry protein ROP 2 is inserted into the parasitophorous vacuole membrane, surrounding the intracellular parasite, and is exposed to the host cell cytoplasm.
    J Cell Biol. 1994 Nov;127(4):947-61 PMID: 7962077
  107. Structure and function of the parasitophorous vacuole membrane surrounding Toxoplasma gondii.
    Ann N Y Acad Sci. 1994 Aug 15;730:1-6 PMID: 8080165
  108. Effects of human class I transgenes on Toxoplasma gondii cyst formation.
    J Immunol. 1994 May 1;152(9):4537-41 PMID: 8157968
  109. Reduced replication of Toxoplasma gondii is necessary for induction of bradyzoite-specific antigens: a possible role for nitric oxide in triggering stage conversion.
    Infect Immun. 1994 May;62(5):1761-7 PMID: 8168938
  110. Effect of the strain of Toxoplasma gondii on the development of toxoplasmic encephalitis in mice treated with antibody to interferon-gamma.
    Parasitol Res. 1994;80(2):125-30 PMID: 8202451
  111. Endocytosis at the micropore of Toxoplasma gondii.
    Parasitol Res. 1994;80(2):91-8 PMID: 8202461
  112. Experimental induction of bradyzoite-specific antigen expression and cyst formation by the RH strain of Toxoplasma gondii in vitro.
    Exp Parasitol. 1994 Jun;78(4):361-70 PMID: 8206135
  113. Loss of stages after continuous passage of Toxoplasma gondii and Besnoitia jellisoni.
    J Protozool. 1976 Aug;23(3):421-4 PMID: 823327
  114. Association of host cell mitochondria with developing Toxoplasma gondii tissue cysts.
    Am J Vet Res. 1993 Oct;54(10):1663-7 PMID: 8250391
  115. Development of an in vitro model of Toxoplasma gondii cyst formation.
    FEMS Microbiol Lett. 1993 Dec 15;114(3):325-32 PMID: 8288109
  116. The parasitophorous vacuole membrane surrounding intracellular Toxoplasma gondii functions as a molecular sieve.
    Proc Natl Acad Sci U S A. 1994 Jan 18;91(2):509-13 PMID: 8290555
  117. Toxoplasma gondii: differential location of antigens secreted from encysted bradyzoites.
    Exp Parasitol. 1993 Aug;77(1):13-22 PMID: 8344403
  118. Influence of genes within the MHC on mortality and brain cyst development in mice infected with Toxoplasma gondii: kinetics of immune regulation in BALB H-2 congenic mice.
    Parasite Immunol. 1993 Jun;15(6):317-24 PMID: 8361774
  119. Clinical segmental myelitis associated with an unidentified Toxoplasma-like parasite in a cat.
    J Vet Diagn Invest. 1993 Jul;5(3):472-80 PMID: 8373868
  120. Subcellular organelles of Toxoplasma gondii and host cell invasion.
    Res Immunol. 1993 Jan;144(1):31-3 PMID: 8383871
  121. Cell entry by Toxoplasma gondii: all paths do not lead to success.
    Res Immunol. 1993 Jan;144(1):34-8 PMID: 8383872
  122. Coexistence of heterogeneous populations of Toxoplasma gondii parasites within parasitophorous vacuoles of murine macrophages as revealed by a bradyzoite-specific monoclonal antibody.
    Parasitol Res. 1993;79(6):485-7 PMID: 8415563
  123. Induction of bradyzoite-specific Toxoplasma gondii antigens in gamma interferon-treated mouse macrophages.
    Infect Immun. 1993 Mar;61(3):1141-5 PMID: 8432596
  124. Ultrastructural determination of cystogenesis by various Toxoplasma gondii isolates in cell culture.
    J Parasitol. 1993 Apr;79(2):289-92 PMID: 8459343
  125. Susceptibility to chronic infection with Toxoplasma gondii does not correlate with susceptibility to acute infection in mice.
    Infect Immun. 1993 Jun;61(6):2284-8 PMID: 8500870
  126. Separation of toxoplasma cysts from brain tissue and liberation of viable bradyzoites.
    J Parasitol. 1995 Dec;81(6):1008-10 PMID: 8544039
  127. Monoclonal rat antibodies directed against Toxoplasma gondii suitable for studying tachyzoite-bradyzoite interconversion in vivo.
    Clin Diagn Lab Immunol. 1995 Sep;2(5):542-8 PMID: 8548532
  128. Cloning and characterization of a bradyzoite-specifically expressed gene (hsp30/bag1) of Toxoplasma gondii, related to genes encoding small heat-shock proteins of plants.
    Mol Microbiol. 1995 Jun;16(6):1221-30 PMID: 8577255
  129. Quantification of Toxoplasma gondii bradyzoites.
    J Parasitol. 1996 Apr;82(2):330-2 PMID: 8604108
  130. Interconnection between organellar functions, development and drug resistance in the protozoan parasite, Toxoplasma gondii.
    Int J Parasitol. 1995 Nov;25(11):1293-9 PMID: 8635881
  131. Infectivity of low numbers of Toxoplasma gondii oocysts to pigs.
    J Parasitol. 1996 Jun;82(3):438-43 PMID: 8636849
  132. Sporozoites of Toxoplasma gondii lack dense-granule protein GRA3 and form a unique parasitophorous vacuole.
    Mol Biochem Parasitol. 1995 Dec;75(1):75-86 PMID: 8720177
  133. Toxoplasma gondii: appearance of specific markers during the development of tissue cysts in vitro.
    Parasitol Res. 1996;82(4):340-6 PMID: 8740550
  134. Regulation of developmental differentiation in the protozoan parasite Toxoplasma gondii.
    J Eukaryot Microbiol. 1996 Sep-Oct;43(5):114S-116S PMID: 8822898
  135. The association of the stress response and Toxoplasma gondii bradyzoite development.
    J Eukaryot Microbiol. 1996 Sep-Oct;43(5):120S PMID: 8822901
  136. Stage conversion of Toxoplasma gondii in mouse brain during infection and immunodepression.
    Parasitol Res. 1996;82(1):28-31 PMID: 8825441
  137. The stage-conversion time of Toxoplasma gondii: interpretation of chemical-biologic data out of parasitologic or host context.
    Parasitol Res. 1996;82(7):656-8 PMID: 8875575
  138. Effect of immunosuppressive drug regimens on acute and chronic murine toxoplasmosis.
    Parasitol Res. 1996;82(8):681-6 PMID: 8897501
  139. Mechanisms of interferon-induced inhibition of Toxoplasma gondii replication in human retinal pigment epithelial cells.
    Infect Immun. 1996 Oct;64(10):4188-96 PMID: 8926087
  140. Growth and development of Toxoplasma gondii in human neurons and astrocytes.
    J Neuropathol Exp Neurol. 1996 Nov;55(11):1150-6 PMID: 8939198
  141. [Structure and biology of Toxoplasma gondii bradyzoites].
    C R Seances Soc Biol Fil. 1996;190(4):385-94 PMID: 8952889
  142. TNF-alpha enhances Toxoplasma gondii cyst formation in human fibroblasts through the sphingomyelinase pathway.
    Cell Signal. 1996 Sep;8(6):439-42 PMID: 8958446
  143. Pathogenicity and infectivity of Toxoplasma gondii oocysts for rats.
    J Parasitol. 1996 Dec;82(6):951-6 PMID: 8973405
  144. Infectivity and pathogenicity of Toxoplasma gondii oocysts for cats.
    J Parasitol. 1996 Dec;82(6):957-61 PMID: 8973406
  145. Subpellicular microtubules associate with an intramembranous particle lattice in the protozoan parasite Toxoplasma gondii.
    J Cell Sci. 1997 Jan;110 ( Pt 1):35-42 PMID: 9010782
  146. A plastid of probable green algal origin in Apicomplexan parasites.
    Science. 1997 Mar 7;275(5305):1485-9 PMID: 9045615
  147. Toxoplasma gondii: in vivo and in vitro cystogenesis of the virulent RH strain.
    J Parasitol. 1997 Feb;83(1):152-5 PMID: 9057714
  148. A cytochemistry study of the inner membrane complex of the pellicle of tachyzoites of Toxoplasma gondii.
    Parasitol Res. 1997;83(3):252-6 PMID: 9089721
  149. Bradyzoite-specific gene expression in Toxoplasma gondii requires minimal genomic elements.
    Mol Biochem Parasitol. 1997 Mar;85(1):89-98 PMID: 9108551
  150. A mouse model of recrudescence of Toxoplasma gondii infection.
    J Med Microbiol. 1997 Mar;46(3):263-6 PMID: 9126829
  151. Parasitemia and parasitic loads in acute infection and after anti-gamma-interferon treatment in a toxoplasmic mouse model.
    Parasitol Res. 1997;83(4):339-44 PMID: 9134554
  152. Toxoplasma gondii: the growth characteristics of three virulent strains.
    Acta Trop. 1997 May 15;65(2):97-104 PMID: 9164603
  153. Tissue cyst tropism in Toxoplasma gondii: a comparison of tissue cyst formation in organs of cats, and rodents fed oocysts.
    Parasitology. 1997 Jul;115 ( Pt 1):15-20 PMID: 9226953
  154. Time lapse video microscopy and ultrastructure of penetrating sporozoites, types 1 and 2 parasitophorous vacuoles, and the transformation of sporozoites to tachyzoites of the VEG strain of Toxoplasma gondii.
    J Parasitol. 1997 Aug;83(4):565-74 PMID: 9267394
  155. Distribution of tissue cysts in organs of rats fed Toxoplasma gondii oocysts.
    J Parasitol. 1997 Aug;83(4):755-7 PMID: 9267423
  156. Host cells of Toxoplasma gondii encystation in infected primary culture from mouse brain.
    Parasitol Res. 1997;83(7):637-41 PMID: 9272550
  157. Cyst formation by Toxoplasma gondii in vivo and in brain-cell culture: a comparative morphology and immunocytochemistry study.
    Parasitol Res. 1997;83(7):659-65 PMID: 9272554
  158. Stage-specific expression of a selectable marker in Toxoplasma gondii permits selective inhibition of either tachyzoites or bradyzoites.
    Mol Biochem Parasitol. 1997 Sep;88(1-2):115-26 PMID: 9274873
  159. Oocyst-induced murine toxoplasmosis: life cycle, pathogenicity, and stage conversion in mice fed Toxoplasma gondii oocysts.
    J Parasitol. 1997 Oct;83(5):870-82 PMID: 9379292
  160. Survival of Toxoplasma gondii tissue cysts in 0.85-6% NaCl solutions at 4-20 C.
    J Parasitol. 1997 Oct;83(5):946-9 PMID: 9379305
  161. Bradyzoite-induced murine toxoplasmosis: stage conversion, pathogenesis, and tissue cyst formation in mice fed bradyzoites of different strains of Toxoplasma gondii.
    J Eukaryot Microbiol. 1997 Nov-Dec;44(6):592-602 PMID: 9435131
  162. Mechanical transmission of Toxoplasma gondii oocysts by dogs.
    Vet Parasitol. 1997 Dec 15;73(1-2):27-33 PMID: 9477489
  163. Ultrastructure of early stages of infections in mice fed Toxoplasma gondii oocysts.
    Parasitology. 1998 Jan;116 ( Pt 1):35-42 PMID: 9481772
  164. Re-examination of resistance of Toxoplasma gondii tachyzoites and bradyzoites to pepsin and trypsin digestion.
    Parasitology. 1998 Jan;116 ( Pt 1):43-50 PMID: 9481773
  165. Advances in the life cycle of Toxoplasma gondii.
    Int J Parasitol. 1998 Jul;28(7):1019-24 PMID: 9724872
Article Info
Journal
Clinical microbiology reviews
Abbr.
Clin Microbiol Rev
ISSN
0893-8512
DOI
10.1128/CMR.11.2.267
Email
jdubey@ggpl.arsusda.gov
Published
1998-04-00
Pages
267-99
Language
English
Region
United States
NLM ID
8807282
PMCID
PMC106833
Subset
IM
External Links
PubMed source DOI: 10.1128/CMR.11.2.267 PMC Full Text View journal details
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