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PMID: 9547239 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Development of bone morphogenetic protein receptors in the nervous system and possible roles in regulating trkC expression.

The Journal of neuroscience : the official journal of the Society for Neuroscience ·Vol. 18 ·No. 9 ·1998-05-01 ·Pages 3314-26

Zhang D, Mehler MF, Song Q, Kessler JA

Abstract

Characterization of bone morphogenetic protein receptor (BMPR) expression during development is necessary for understanding the role of these factors during neural maturation. In this study, in situ hybridization analyses demonstrate that BMP-specific type I (BMPR-IA and BMPR-IB) and type II (BMPR-II) receptor mRNAs are expressed at significant levels in multiple regions of the CNS, cranial ganglia, and peripheral sensory and autonomic ganglia during the embryonic and neonatal periods. All three BMP receptor subunits are expressed within periventricular generative zones. BMPR-IA is more abundant than the other receptor subtypes, with widespread expression in the brain, cranial ganglia, and peripheral ganglia. By contrast, BMPR-IB mRNA displays significant expression within more restricted regions, including the anterior olfactory nuclei. BMPR-II mRNA exhibits peak expression within the cerebellar Purkinje cell layer and the hippocampus, as well as within cranial ganglia. The distribution of BMP receptors within large neurons in adult dorsal root ganglia suggested a possible role in regulating expression of the neurotrophin receptor trkC. This hypothesis was tested in explant cultures of embryonic day 15 (E15) and postnatal day 1 (P1) sympathetic superior cervical ganglia (SCG). Treatment of the E15 or the P1 SCG with BMP-2 induced expression of trkC mRNA and responsiveness of sympathetic neurons to NT3 as measured by neurite outgrowth. The pattern of expression of BMP receptors in embryonic brain suggests several potentially novel areas for further developmental analysis and supports numerous recent studies that indicate that BMPs have a broad range of cellular functions during neural development and in adult life.

MeSH Terms
Animals Bone Morphogenetic Protein Receptors Bone Morphogenetic Protein Receptors, Type I Brain/physiology Embryonic and Fetal Development/physiology Ganglia, Spinal/physiology Ganglia, Sympathetic/physiology In Situ Hybridization Mice Nerve Growth Factors/biosynthesis Nervous System/embryology,growth & development Nervous System Physiological Phenomena Neurotrophin 3 Peptide Fragments/physiology RNA, Messenger/biosynthesis Receptor Protein-Tyrosine Kinases/biosynthesis Receptor, trkC Receptors, Cell Surface/genetics,physiology Receptors, Growth Factor Receptors, Nerve Growth Factor/biosynthesis Superior Cervical Ganglion/physiology
Chemicals
Nerve Growth Factors Neurotrophin 3 Peptide Fragments RNA, Messenger Receptors, Cell Surface Receptors, Growth Factor Receptors, Nerve Growth Factor Receptor Protein-Tyrosine Kinases Receptor, trkC BMPR1A protein, human Bone Morphogenetic Protein Receptors Bone Morphogenetic Protein Receptors, Type I
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Zhang D
Department of Neurology, Albert Einstein College of Medicine, Bronx, New York 10461, USA.
Mehler M F
Song Q
Kessler J A
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Article Info
Journal
The Journal of neuroscience : the official journal of the Society for Neuroscience
Abbr.
J Neurosci
ISSN
0270-6474
Published
1998-05-01
Pages
3314-26
Language
English
Region
United States
NLM ID
8102140
PMCID
PMC6792660
Subset
IM
Grants
NIMH NIH HHS · R01 MH066290 · United States
NINDS NIH HHS · NS20013 · United States
NINDS NIH HHS · NS20778 · United States
NINDS NIH HHS · NS35320 · United States
External Links
PubMed source PMC Full Text View journal details
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