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PMID: 8752215 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

The Xenopus dorsalizing factor noggin ventralizes Drosophila embryos by preventing DPP from activating its receptor.

Cell ·Vol. 86 ·No. 4 ·1996-08-23 ·Pages 607-17

Holley SA, Neul JL, Attisano L, Wrana JL, Sasai Y, O'Connor MB, De Robertis EM, Ferguson EL

Abstract

noggin is expressed in the Spemann organizer region of the Xenopus embryo and can promote dorsal cell fates within the mesoderm and neural development within the overlying ectoderm. Here, we show that noggin promotes ventral development in Drosophila, specifying ventral ectoderm and CNS in the absence of all endogenous ventral-specific zygotic gene expression. We utilize constitutively active forms of the dpp receptors to demonstrate that noggin blocks dpp signaling upstream of dpp receptor activation. These results suggest a mechanistic basis for the action of Spemann's organizer during Xenopus development and provide further support for the conservation of dorsal-ventral patterning mechanisms between arthropods and chordates.

MeSH Terms

Activin Receptors Animals Base Sequence Bone Morphogenetic Proteins Carrier Proteins DNA Primers/chemistry Drosophila Proteins Drosophila melanogaster/embryology Ectoderm/cytology Embryonic Induction Epistasis, Genetic Female Humans Insect Hormones/physiology Male Microinjections Molecular Sequence Data Morphogenesis Protein Serine-Threonine Kinases/physiology Proteins/pharmacology,physiology RNA, Messenger/administration & dosage Receptors, Cell Surface/physiology Receptors, Growth Factor/physiology Recombinant Proteins Signal Transduction Species Specificity Xenopus laevis/embryology

Chemicals

Bone Morphogenetic Proteins Carrier Proteins DNA Primers Drosophila Proteins Insect Hormones Proteins RNA, Messenger Receptors, Cell Surface Receptors, Growth Factor Recombinant Proteins dpp protein, Drosophila noggin protein tkv protein, Drosophila Protein Serine-Threonine Kinases Activin Receptors

Authors & Affiliations

8 authors, click to expand affiliations / ORCID

Holley S A

Department of Molecular Genetics and Cell Biology, University of Chicago, Illinois 60637, USA.

Neul J L

Attisano L

Wrana J L

Sasai Y

O'Connor M B

De Robertis E M

Ferguson E L

Article Info

Journal

Cell

Abbr.

Cell

ISSN

0092-8674

DOI

10.1016/s0092-8674(00)80134-8

Published

1996-08-23

Pages

607-17

Language

English

Region

United States

NLM ID

0413066

Subset

Grants

NIGMS NIH HHS · GM47462 · United States

NIGMS NIH HHS · GM50838 · United States

NICHD NIH HHS · HD21503 · United States

External Links

PubMed source DOI: 10.1016/s0092-8674(00)80134-8 View journal details

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The Xenopus dorsalizing factor noggin ventralizes Drosophila embryos by preventing DPP from activating its receptor.

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