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PMID: 950602 Published · ppublish English Journal Article

Subcellular localization of the heparin-neutralizing factor in blood platelets.

The Journal of physiology ·Vol. 257 ·No. 2 ·1976-05-00 ·Pages 495-502

Da Prada M, Jakábová M, Lüscher EF, Pletscher A, Richards JG

Abstract

1. The distribution of the heparin-neutralizing factor (platelet factor 4, PF4) in subcellular organelles of blood platelets of rabbits and man was investigated. 2. In both species the organelles storing 5-hydroxytryptamine (5-HT storage organelles) contained only trivial amounts of PF4. 3. In contrast, the content of PF4 was highest in the subcellular fractions rich in alpha-granules. 4. In conclusion, PF4 is probably localized in the alpha-granules and therefore the platelets contain at least two types of organelles (5-HT organelles and alpha-granules) capable of releasing their contents in response to the same stimuli, such as exposure to collagen, thrombin, etc.

MeSH Terms
Animals Blood Coagulation Factors/analysis Blood Platelets/analysis,ultrastructure Humans Platelet Factor 4/analysis Rabbits Serotonin/analysis Subcellular Fractions/analysis
Chemicals
Blood Coagulation Factors Serotonin Platelet Factor 4
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Da Prada M
Jakábová M
Lüscher E F
Pletscher A
Richards J G
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Article Info
Journal
The Journal of physiology
Abbr.
J Physiol
ISSN
0022-3751
DOI
10.1113/jphysiol.1976.sp011380
Published
1976-05-00
Pages
495-502
Language
English
Region
England
NLM ID
0266262
PMCID
PMC1309371
Subset
IM
External Links
PubMed source DOI: 10.1113/jphysiol.1976.sp011380 PMC Full Text View journal details
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