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PMID: 9499029 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Effect of passive immunization or maternally transferred immunity on the antibody response to a genetic vaccine to rabies virus.

Journal of virology ·Vol. 72 ·No. 3 ·1998-03-00 ·Pages 1790-6

Wang Y, Xiang Z, Pasquini S, Ertl HC

Abstract

A plasmid vector, termed pSG5rab.gp, expressing the glycoprotein of rabies virus was tested in young adult or neonatal mice in the presence of maternally transferred immunity or passively administered antibodies to rabies virus for induction of an antibody response. Mice born to rabies virus-immune dams developed an impaired antibody response to genetic immunization at 6 weeks of age, as had been previously observed upon vaccination with an inactivated viral vaccine. Similarly, mice passively immunized with hyperimmune serum showed an inhibited B-cell response upon vaccination with the pSG5rab.gp vector, resulting in both cases in vaccine failures upon challenge with a virulent strain of rabies virus. In contrast, the immune responses of mice vaccinated as neonates in the presence of maternal immunity or upon passive immunization to rabies virus with the pSG5rab.gp construct were only marginally affected.

MeSH Terms
Animals Animals, Newborn Antibodies, Viral/immunology Antigens, Viral Cell Line Cricetinae Female Glycoproteins/immunology Immunity, Maternally-Acquired/immunology Immunization, Passive Immunoglobulin Isotypes Male Mice Mice, Inbred C3H Rabies Vaccines/immunology Rabies virus/immunology Vaccines, Inactivated/immunology Vaccines, Synthetic/immunology Viral Envelope Proteins/immunology
Chemicals
Antibodies, Viral Antigens, Viral Glycoproteins Immunoglobulin Isotypes Rabies Vaccines Vaccines, Inactivated Vaccines, Synthetic Viral Envelope Proteins adenovirus 5, rabies glycoprotein recombinant vaccine glycoprotein G, Rabies virus
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Wang Y
The Wistar Institute, Philadelphia, Pennsylvania 19104-4268, USA.
Xiang Z
Pasquini S
Ertl H C
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.72.3.1790-1796.1998
Published
1998-03-00
Pages
1790-6
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC109468
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.72.3.1790-1796.1998 PMC Full Text View journal details
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