Neonatal tolerance revisited: turning on newborn T cells with dendritic cells.

Science (New York, N.Y.) ·Vol. 271 ·No. 5256 ·1996-03-22 ·Pages 1723-6

Ridge JP, Fuchs EJ, Matzinger P

Abstract

For some time it has been thought that antigenic challenge in neonatal life is a tolerogenic rather than immunogenic event. Reexamination of the classic neonatal tolerance experiments of Billingham, Brent, and Medawar showed that tolerance is not an intrinsic property of the newborn immune system, but that the nature of the antigen-presenting cell determines whether the outcome is neonatal tolerance or immunization.

MeSH Terms

Animals Animals, Newborn/immunology B-Lymphocytes/immunology Cytotoxicity Tests, Immunologic Cytotoxicity, Immunologic Dendritic Cells/immunology Female H-Y Antigen/immunology Immune Tolerance Immunization Male Mice Mice, Inbred C57BL Self Tolerance T-Lymphocytes/immunology

Chemicals

H-Y Antigen

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Ridge J P

Laboratory of Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA.

Fuchs E J

Matzinger P

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.271.5256.1723

Published

1996-03-22

Pages

1723-6

Language

English

Region

United States

NLM ID

0404511

Subset

Corrections

CommentIn

PMID: 8596923

CommentIn

PMID: 8633222

CommentIn

PMID: 8633223

CommentIn

PMID: 8701318

CommentIn

PMID: 8801631

External Links

PubMed source DOI: 10.1126/science.271.5256.1723 View journal details

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Neonatal tolerance revisited: turning on newborn T cells with dendritic cells.

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