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PMID: 9440531 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Staphylococcus aureus cap5O and cap5P genes functionally complement mutations affecting enterobacterial common-antigen biosynthesis in Escherichia coli.

Journal of bacteriology ·Vol. 180 ·No. 2 ·1998-01-00 ·Pages 403-6

Kiser KB, Lee JC

Abstract

The Staphylococcus aureus cap5P and cap5O genes of the type 5 capsule biosynthetic locus restore enterobacterial common-antigen expression to Escherichia coli mutants defective in rffE and rffD gene expression, respectively. Cap5P and Cap5O likely function as UDP-GlcNAc 2-epimerase and UDP-ManNAc dehydrogenase enzymes, respectively, in the synthesis of the capsule precursor UDP-ManNAcA.

MeSH Terms

Antigens, Bacterial/genetics Carbohydrate Sequence Escherichia coli/genetics,immunology Genes, Bacterial Genetic Complementation Test Molecular Sequence Data Mutation Staphylococcus aureus/genetics,immunology

Chemicals

Antigens, Bacterial

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Kiser K B

Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts 02115, USA.

Lee J C

References (15)

15 references, click to expand

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Article Info

Journal

Journal of bacteriology

Abbr.

J Bacteriol

ISSN

0021-9193

DOI

10.1128/JB.180.2.403-406.1998

Published

1998-01-00

Pages

403-6

Language

English

Region

United States

NLM ID

2985120R

PMCID

PMC106897

Subset

Grants

NIAID NIH HHS · R01 AI029040 · United States

NIAID NIH HHS · T32-AI07410 · United States

NIAID NIH HHS · AI29040 · United States

NIAID NIH HHS · R21 AI029040 · United States

NIAID NIH HHS · T32 AI007410 · United States

Databases

GENBANK

U81973

External Links

PubMed source DOI: 10.1128/JB.180.2.403-406.1998 PMC Full Text View journal details

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Staphylococcus aureus cap5O and cap5P genes functionally complement mutations affecting enterobacterial common-antigen biosynthesis in Escherichia coli.

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