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PMID: 9422610 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Stability of the Escherichia coli division inhibitor protein MinC requires determinants in the carboxy-terminal region of the protein.

Journal of bacteriology ·Vol. 180 ·No. 1 ·1998-01-00 ·Pages 175-7

Sen M, Rothfield LI

Abstract

Certain mutations in the C-terminal region of the Escherichia coli division inhibitor protein MinC cause loss of function of the division inhibitor by making MinC more sensitive to degradation by Lon protease, implying a possible role for the C-terminal region in regulating the stability and cellular concentration of MinC.

MeSH Terms
ATP-Dependent Proteases Bacterial Proteins/analysis,chemistry,genetics Cell Division Escherichia coli/cytology,genetics Escherichia coli Proteins Heat-Shock Proteins/metabolism Mutation Phenotype Protease La Serine Endopeptidases/metabolism
Chemicals
Bacterial Proteins Escherichia coli Proteins Heat-Shock Proteins MinC protein, Bacteria ATP-Dependent Proteases Serine Endopeptidases Lon protein, E coli Protease La
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Sen M
Department of Microbiology, University of Connecticut Health Center, Farmington 06032, USA.
Rothfield L I
References (6)
6 references, click to expand
  1. Roles of MinC and MinD in the site-specific septation block mediated by the MinCDE system of Escherichia coli.
    J Bacteriol. 1992 Jan;174(1):63-70 PMID: 1729224
  2. Isolation and properties of minB, a complex genetic locus involved in correct placement of the division site in Escherichia coli.
    J Bacteriol. 1988 May;170(5):2106-12 PMID: 2834323
  3. Cell division inhibition gene dicB is regulated by a locus similar to lambdoid bacteriophage immunity loci.
    Mol Gen Genet. 1988 Apr;212(1):11-9 PMID: 2836697
  4. A division inhibitor and a topological specificity factor coded for by the minicell locus determine proper placement of the division septum in E. coli.
    Cell. 1989 Feb 24;56(4):641-9 PMID: 2645057
  5. Central role for the Escherichia coli minC gene product in two different cell division-inhibition systems.
    Proc Natl Acad Sci U S A. 1990 Feb;87(3):1129-33 PMID: 2137246
  6. New minC mutations suggest different interactions of the same region of division inhibitor MinC with proteins specific for minD and dicB coinhibition pathways.
    J Bacteriol. 1992 Jan;174(1):35-9 PMID: 1729222
Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/JB.180.1.175-177.1998
Published
1998-01-00
Pages
175-7
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC106866
Subset
IM
External Links
PubMed source DOI: 10.1128/JB.180.1.175-177.1998 PMC Full Text View journal details
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