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PMID: 9420057 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Selection of multiple-antibiotic-resistant (mar) mutants of Escherichia coli by using the disinfectant pine oil: roles of the mar and acrAB loci.

Antimicrobial agents and chemotherapy ·Vol. 41 ·No. 12 ·1997-12-00 ·Pages 2770-2

Moken MC, McMurry LM, Levy SB

Abstract

Mutants of Escherichia coli selected for resistance to the disinfectant pine oil or to a household product containing pine oil also showed resistance to multiple antibiotics (tetracycline, ampicillin, chloramphenicol, and nalidixic acid) and overexpressed the marA gene. Likewise, antibiotic-selected Mar mutants, which also overexpress marA, were resistant to pine oil. Deletion of the mar or acrAB locus, the latter encoding a multidrug efflux pump positively regulated in part by MarA, increased the susceptibility of wild-type and mutant strains to pine oil.

MeSH Terms
Ampicillin/pharmacology Chloramphenicol/pharmacology Disinfectants/pharmacology Drug Resistance, Multiple/genetics Escherichia coli/drug effects,genetics Genes, Bacterial Mutation Nalidixic Acid/pharmacology Phenotype Plant Oils/pharmacology Tetracycline/pharmacology
Chemicals
Disinfectants Plant Oils Nalidixic Acid Chloramphenicol Ampicillin Tetracycline
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Moken M C
McMurry L M
Levy S B
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26 references, click to expand
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Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.41.12.2770
Published
1997-12-00
Pages
2770-2
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC164207
Subset
IM
Grants
NIGMS NIH HHS · GM51661 · United States
External Links
PubMed source DOI: 10.1128/AAC.41.12.2770 PMC Full Text View journal details
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