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PMID: 9356487 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Dendritic cell ontogeny: a human dendritic cell lineage of myeloid origin.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 94 ·No. 23 ·1997-11-11 ·Pages 12551-6

Olweus J, BitMansour A, Warnke R, Thompson PA, Carballido J, Picker LJ, Lund-Johansen F

Abstract

Dendritic cells (DC) have been thought to represent a family of closely related cells with similar functions and developmental pathways. The best-characterized precursors are the epidermal Langerhans cells, which migrate to lymphoid organs and become activated DC in response to inflammatory stimuli. Here, we demonstrate that a large subset of DC in the T cell-dependent areas of human lymphoid organs are nonactivated cells and belong to a separate lineage that can be identified by high levels of the interleukin 3 receptor alpha chain (IL-3Ralphahi). The CD34+IL-3Ralphahi DC progenitors are of myeloid origin and are distinct from those that give rise to Langerhans cells in vitro. The IL-3Ralphahi DC furthermore appear to migrate to lymphoid organs independently of inflammatory stimuli or foreign antigens. Thus, DC are heterogeneous with regard to function and ontogeny.

MeSH Terms
Cell Lineage Dendritic Cells/cytology,immunology Humans Interleukin-3/immunology Leukocytes/cytology,immunology Lymphoid Tissue/cytology,immunology Receptors, Interleukin-3/immunology
Chemicals
Interleukin-3 Receptors, Interleukin-3
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Olweus J
Becton Dickinson Immunocytometry Systems, 2350 Qume Drive, San Jose, CA 95131, USA.
BitMansour A
Warnke R
Thompson P A
Carballido J
Picker L J
Lund-Johansen F
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.94.23.12551
Published
1997-11-11
Pages
12551-6
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC25034
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.94.23.12551 PMC Full Text View journal details
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