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PMID: 9314535 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Positive and negative regulation of muscle cell identity by members of the hedgehog and TGF-beta gene families.

The Journal of cell biology ·Vol. 139 ·No. 1 ·1997-10-06 ·Pages 145-56

Du SJ, Devoto SH, Westerfield M, Moon RT

Abstract

We have examined whether the development of embryonic muscle fiber type is regulated by competing influences between Hedgehog and TGF-beta signals, as previously shown for development of neuronal cell identity in the neural tube. We found that ectopic expression of Hedgehogs or inhibition of protein kinase A in zebrafish embryos induces slow muscle precursors throughout the somite but muscle pioneer cells only in the middle of the somite. Ectopic expression in the notochord of Dorsalin-1, a member of the TGF-beta superfamily, inhibits the formation of muscle pioneer cells, demonstrating that TGF-beta signals can antagonize the induction of muscle pioneer cells by Hedgehog. We propose that a Hedgehog signal first induces the formation of slow muscle precursor cells, and subsequent Hedgehog and TGF-beta signals exert competing positive and negative influences on the development of muscle pioneer cells.

MeSH Terms
Animals Cell Differentiation Cyclic AMP-Dependent Protein Kinases/antagonists & inhibitors,physiology Down-Regulation/genetics Drosophila Drosophila Proteins Embryo, Nonmammalian Gene Expression Regulation, Developmental Hedgehog Proteins Insect Proteins/biosynthesis,genetics,physiology Multigene Family Muscle Fibers, Skeletal/cytology,enzymology,physiology Muscle Fibers, Slow-Twitch/cytology,physiology Notochord/metabolism Signal Transduction Transforming Growth Factor beta/genetics,physiology Transforming Growth Factors/biosynthesis,physiology Up-Regulation/genetics Zebrafish Zebrafish Proteins
Chemicals
Drosophila Proteins Hedgehog Proteins Insect Proteins Transforming Growth Factor beta Zebrafish Proteins hh protein, Drosophila Transforming Growth Factors Cyclic AMP-Dependent Protein Kinases
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Du S J
Howard Hughes Medical Institute, University of Washington, School of Medicine, Seattle 98195, USA.
Devoto S H
Westerfield M
Moon R T
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Article Info
Journal
The Journal of cell biology
Abbr.
J Cell Biol
ISSN
0021-9525
DOI
10.1083/jcb.139.1.145
Published
1997-10-06
Pages
145-56
Language
English
Region
United States
NLM ID
0375356
PMCID
PMC2139815
Subset
IM
Grants
NICHD NIH HHS · HD22486 · United States
NICHD NIH HHS · HD29360 · United States
NINDS NIH HHS · NS21132 · United States
External Links
PubMed source DOI: 10.1083/jcb.139.1.145 PMC Full Text View journal details
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