Home LiteratureArticle Details
PMID: 7477317 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

A homeobox gene essential for zebrafish notochord development.

Nature ·Vol. 378 ·No. 6553 ·1995-11-09 ·Pages 150-7

Talbot WS, Trevarrow B, Halpern ME, Melby AE, Farr G, Postlethwait JH, Jowett T, Kimmel CB, Kimelman D

Abstract

The notochord is a midline mesodermal structure with an essential patterning function in all vertebrate embryos. Zebrafish floating head (flh) mutants lack a notochord, but develop with prechordal plate and other mesodermal derivatives, indicating that flh functions specifically in notochord development. We show that floating head is the zebrafish homologue of Xnot, a homeobox gene expressed in the amphibian organizer and notochord. We propose that flh regulates notochord precursor cell fate.

MeSH Terms
Amino Acid Sequence Animals Base Sequence Cell Differentiation/genetics Chromosome Mapping DNA Primers DNA-Binding Proteins/genetics Gastrula/cytology Genes, Homeobox Genes, Lethal Hedgehog Proteins Homeodomain Proteins/genetics Humans Mesoderm/cytology Molecular Sequence Data Motor Neurons/cytology Mutation Notochord/embryology Proteins/genetics RNA, Messenger/biosynthesis Stem Cells/cytology Tail Trans-Activators/genetics Transcription Factors/genetics Xenopus Proteins Zebrafish Zebrafish Proteins
Chemicals
DNA Primers DNA-Binding Proteins Hedgehog Proteins Homeodomain Proteins Not protein, Xenopus Proteins RNA, Messenger Trans-Activators Transcription Factors Xenopus Proteins Zebrafish Proteins noto protein, zebrafish
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Talbot W S
Institute of Neuroscience, University of Oregon, Eugene 97403, USA.
Trevarrow B
Halpern M E
Melby A E
Farr G
Postlethwait J H
Jowett T
Kimmel C B
Kimelman D
Article Info
Journal
Nature
Abbr.
Nature
ISSN
0028-0836
DOI
10.1038/378150a0
Published
1995-11-09
Pages
150-7
Language
English
Region
England
NLM ID
0410462
Subset
IM
Grants
Wellcome Trust · United Kingdom
Databases
GENBANK
L48017
External Links
PubMed source DOI: 10.1038/378150a0 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2