Home LiteratureArticle Details
PMID: 9311896 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't

Langerhans cell tropism of human immunodeficiency virus type 1 subtype A through F isolates derived from different transmission groups.

Journal of virology ·Vol. 71 ·No. 10 ·1997-10-00 ·Pages 8008-13

Dittmar MT, Simmons G, Hibbitts S, O'Hare M, Louisirirotchanakul S, Beddows S, Weber J, Clapham PR, Weiss RA

Abstract

To test the hypothesis that some subtypes of human immunodeficiency virus type 1 (HIV-1), especially subtype E, are more likely to infect mature Langerhans cells (mLC), we titrated a panel of 26 primary HIV-1 isolates of subtypes A through F on peripheral blood mononuclear cells (PBMC) and mLC. The majority of HIV-1 isolates from heterosexually infected patients did not show a preferred tropism for mLC compared to homosexually transmitted HIV-1 isolates. Only 6 of 26 isolates, 2 from patients infected by homosexual contact and 4 from patients infected by heterosexual contact, showed a higher infectivity for mLC than for PBMC. Both syncytium-inducing and non-syncytium-inducing isolates were able to infect mLC which express mRNA for the chemokine receptors CCR3, CCR5, and CXCR4.

MeSH Terms
Acquired Immunodeficiency Syndrome/epidemiology,transmission Cells, Cultured Female HIV-1/classification,genetics,physiology Homosexuality, Male Humans Langerhans Cells/virology Leukocytes/virology Leukocytes, Mononuclear/virology Male Phenotype Risk Factors Sexual Behavior Skin/cytology,virology
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Dittmar M T
Chester Beatty Laboratories, Institute of Cancer Research, London, United Kingdom.
Simmons G
Hibbitts S
O'Hare M
Louisirirotchanakul S
Beddows S
Weber J
Clapham P R
Weiss R A
References (72)
72 references, click to expand
  1. Molecular cloning and functional characterization of a novel human CC chemokine receptor (CCR5) for RANTES, MIP-1beta, and MIP-1alpha.
    J Biol Chem. 1996 Jul 19;271(29):17161-6 PMID: 8663314
  2. Homozygous defect in HIV-1 coreceptor accounts for resistance of some multiply-exposed individuals to HIV-1 infection.
    Cell. 1996 Aug 9;86(3):367-77 PMID: 8756719
  3. Resistance to HIV-1 infection in caucasian individuals bearing mutant alleles of the CCR-5 chemokine receptor gene.
    Nature. 1996 Aug 22;382(6593):722-5 PMID: 8751444
  4. Frequent infection of peripheral blood CD8-positive T-lymphocytes with HIV-1. Edinburgh Heterosexual Transmission Study Group.
    Lancet. 1996 Sep 7;348(9028):649-54 PMID: 8782755
  5. Genetic restriction of HIV-1 infection and progression to AIDS by a deletion allele of the CKR5 structural gene. Hemophilia Growth and Development Study, Multicenter AIDS Cohort Study, Multicenter Hemophilia Cohort Study, San Francisco City Cohort, ALIVE Study.
    Science. 1996 Sep 27;273(5283):1856-62 PMID: 8791590
  6. The heterosexual human immunodeficiency virus type 1 epidemic in Thailand is caused by an intersubtype (A/E) recombinant of African origin.
    J Virol. 1996 Oct;70(10):7013-29 PMID: 8794346
  7. HIV-1 subtype and second-receptor use.
    Nature. 1996 Oct 31;383(6603):768 PMID: 8892998
  8. Host factors and the pathogenesis of HIV-induced disease.
    Nature. 1996 Dec 12;384(6609):529-34 PMID: 8955267
  9. Susceptibility of dendritic cells to HIV-1 infection in vitro.
    J Leukoc Biol. 1994 Sep;56(3):257-65 PMID: 8083598
  10. Experience from HIV incidence cohorts in Thailand: implications for HIV vaccine efficacy trials.
    AIDS. 1994 Jul;8(7):1007-10 PMID: 7946086
  11. Detection of HIV DNA in peripheral blood dendritic cells of HIV-infected individuals.
    Res Virol. 1994 May-Aug;145(3-4):171-6 PMID: 7800942
  12. Genotypic subtypes of HIV-1 in Cameroon.
    AIDS. 1994 Oct;8(10):1405-12 PMID: 7818811
  13. Biological characterization of human immunodeficiency virus type 1 clones derived from different organs of an AIDS patient by long-range PCR.
    J Virol. 1997 Jul;71(7):5140-7 PMID: 9188581
  14. Human mucosal Langerhans cells: postmortem identification of regional variations in oral mucosa.
    J Invest Dermatol. 1984 Jan;82(1):21-4 PMID: 6228611
  15. Epidermal Langerhans cells--a target for HTLV-III/LAV infection.
    J Invest Dermatol. 1987 Feb;88(2):233-7 PMID: 3100656
  16. Susceptibility of human peripheral blood dendritic cells to infection by human immunodeficiency virus.
    J Gen Virol. 1987 Apr;68 ( Pt 4):1177-81 PMID: 3646288
  17. Langerhans cells as primary target cells for HIV infection.
    Lancet. 1987 Nov 7;2(8567):1094 PMID: 2890007
  18. Tumor necrosis factor alpha induces expression of human immunodeficiency virus in a chronically infected T-cell clone.
    Proc Natl Acad Sci U S A. 1989 Apr;86(7):2365-8 PMID: 2784570
  19. Human immunodeficiency virus transmission: is the integument a barrier?
    Am J Med. 1989 Oct;87(4):489 PMID: 2801747
  20. Specific cell surface requirements for the infection of CD4-positive cells by human immunodeficiency virus types 1 and 2 and by Simian immunodeficiency virus.
    Virology. 1991 Apr;181(2):703-15 PMID: 1673040
  21. Morphology and phenotype of dendritic cells from peripheral blood and their productive and non-productive infection with human immunodeficiency virus type 1.
    Immunology. 1991 Mar;72(3):361-7 PMID: 1709140
  22. Replication of human immunodeficiency virus type 1 in primary dendritic cell cultures.
    Proc Natl Acad Sci U S A. 1991 Sep 15;88(18):7998-8002 PMID: 1910172
  23. Viral phenotype and immune response in primary human immunodeficiency virus type 1 infection.
    J Infect Dis. 1992 Mar;165(3):427-32 PMID: 1347054
  24. HIV-1 biological phenotype in long-term infected individuals evaluated with an MT-2 cocultivation assay.
    AIDS. 1992 Jan;6(1):49-54 PMID: 1543566
  25. Primary, syncytium-inducing human immunodeficiency virus type 1 isolates are dual-tropic and most can use either Lestr or CCR5 as coreceptors for virus entry.
    J Virol. 1996 Dec;70(12):8355-60 PMID: 8970955
  26. Efficient interaction of HIV-1 with purified dendritic cells via multiple chemokine coreceptors.
    J Exp Med. 1996 Dec 1;184(6):2433-8 PMID: 8976200
  27. Inhibition of human immunodeficiency virus fusion by a monoclonal antibody to a coreceptor (CXCR4) is both cell type and virus strain dependent.
    J Virol. 1997 Feb;71(2):1692-6 PMID: 8995702
  28. CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia.
    Nature. 1997 Feb 13;385(6617):645-9 PMID: 9024664
  29. Change in coreceptor use correlates with disease progression in HIV-1--infected individuals.
    J Exp Med. 1997 Feb 17;185(4):621-8 PMID: 9034141
  30. The HIV coreceptors CXCR4 and CCR5 are differentially expressed and regulated on human T lymphocytes.
    Proc Natl Acad Sci U S A. 1997 Mar 4;94(5):1925-30 PMID: 9050881
  31. Potent inhibition of HIV-1 infectivity in macrophages and lymphocytes by a novel CCR5 antagonist.
    Science. 1997 Apr 11;276(5310):276-9 PMID: 9092481
  32. Cytokines alter production of HIV-1 from primary mononuclear phagocytes.
    Science. 1988 Sep 23;241(4873):1673-5 PMID: 3047875
  33. Molecular cloning, functional expression, and signaling characteristics of a C-C chemokine receptor.
    Cell. 1993 Feb 12;72(3):415-25 PMID: 7679328
  34. The block to HIV-1 envelope glycoprotein-mediated membrane fusion in animal cells expressing human CD4 can be overcome by a human cell component(s).
    Virology. 1993 Mar;193(1):483-91 PMID: 8438583
  35. Mucosal immunity, HIV transmission, and AIDS.
    Lab Invest. 1993 Feb;68(2):129-45 PMID: 8441249
  36. Different requirements for membrane fusion mediated by the envelopes of human immunodeficiency virus types 1 and 2.
    J Virol. 1993 Apr;67(4):2355-9 PMID: 8095307
  37. In vitro infection of epidermal Langerhans cells with human immunodeficiency virus type 1 (HTLV-IIIB isolate).
    Res Virol. 1993 Jan-Feb;144(1):53-8 PMID: 8446778
  38. Prognostic value of HIV-1 syncytium-inducing phenotype for rate of CD4+ cell depletion and progression to AIDS.
    Ann Intern Med. 1993 May 1;118(9):681-8 PMID: 8096374
  39. Independent introduction of two major HIV-1 genotypes into distinct high-risk populations in Thailand.
    Lancet. 1993 May 8;341(8854):1171-4 PMID: 8098076
  40. The epidemiology of HIV infection and AIDS in Thailand.
    AIDS. 1991;5 Suppl 2:S71-85 PMID: 1845063
  41. Early molecular replication of human immunodeficiency virus type 1 in cultured-blood-derived T helper dendritic cells.
    J Clin Invest. 1993 Jun;91(6):2721-6 PMID: 8514880
  42. Genotypic and phenotypic characterization of HIV-1 patients with primary infection.
    Science. 1993 Aug 27;261(5125):1179-81 PMID: 8356453
  43. Cofactor requirement for human immunodeficiency virus type 1 entry into a CD4-expressing human cell line.
    J Virol. 1993 Oct;67(10):5939-47 PMID: 7690415
  44. Diversity of V3 region sequences of human immunodeficiency viruses type 1 from the central African Republic.
    AIDS Res Hum Retroviruses. 1993 Oct;9(10):997-1006 PMID: 8280481
  45. Proliferating dendritic cell progenitors in human blood.
    J Exp Med. 1994 Jul 1;180(1):83-93 PMID: 8006603
  46. Conjugates of dendritic cells and memory T lymphocytes from skin facilitate productive infection with HIV-1.
    Cell. 1994 Aug 12;78(3):389-98 PMID: 7914836
  47. A novel cell-surface molecule expressed by human interdigitating reticulum cells, Langerhans cells, and activated lymphocytes is a new member of the Ig superfamily.
    J Immunol. 1992 Jul 15;149(2):735-42 PMID: 1378080
  48. Dendritic cells exposed to human immunodeficiency virus type-1 transmit a vigorous cytopathic infection to CD4+ T cells.
    Science. 1992 Jul 17;257(5068):383-7 PMID: 1352913
  49. Mechanism of genital transmission of SIV: a hypothesis based on transmission studies and the location of SIV in the genital tract of chronically infected female rhesus macaques.
    J Med Primatol. 1992 Feb-May;21(2-3):64-8 PMID: 1433268
  50. Genetic variants of HIV-1 in Thailand.
    AIDS Res Hum Retroviruses. 1992 Nov;8(11):1887-95 PMID: 1489577
  51. Rapid genetic characterization of HIV type 1 strains from four World Health Organization-sponsored vaccine evaluation sites using a heteroduplex mobility assay. WHO Network for HIV Isolation and Characterization.
    AIDS Res Hum Retroviruses. 1994 Nov;10(11):1345-53 PMID: 7888187
  52. The World Health Organization Global Programme on AIDS proposal for standardization of HIV sequence nomenclature. WHO Network for HIV Isolation and Characterization.
    AIDS Res Hum Retroviruses. 1994 Nov;10(11):1355-8 PMID: 7888188
  53. Genetic variation of HIV type 1 in four World Health Organization-sponsored vaccine evaluation sites: generation of functional envelope (glycoprotein 160) clones representative of sequence subtypes A, B, C, and E. WHO Network for HIV Isolation and Characterization.
    AIDS Res Hum Retroviruses. 1994 Nov;10(11):1359-68 PMID: 7888189
  54. Antigenic variation and serotyping of HIV type 1 from four World Health Organization-sponsored HIV vaccine sites. WHO Network for HIV Isolation and Characterization.
    AIDS Res Hum Retroviruses. 1994 Nov;10(11):1369-77 PMID: 7888190
  55. Serotyping HIV type 1 by antibody binding to the V3 loop: relationship to viral genotype. WHO Network for HIV Isolation and Characterization.
    AIDS Res Hum Retroviruses. 1994 Nov;10(11):1379-86 PMID: 7888191
  56. Standard conditions of virus isolation reveal biological variability of HIV type 1 in different regions of the world. WHO Network for HIV Isolation and Characterization.
    AIDS Res Hum Retroviruses. 1994 Nov;10(11):1401-8 PMID: 7888193
  57. Change in tropism upon immune escape by human immunodeficiency virus.
    J Virol. 1995 May;69(5):3167-70 PMID: 7707545
  58. Monocyte-derived cultured dendritic cells are susceptible to human immunodeficiency virus infection and transmit virus to resting T cells in the process of nominal antigen presentation.
    J Virol. 1995 Jul;69(7):4544-7 PMID: 7769720
  59. Replication pattern of human immunodeficiency virus type 1 in mature Langerhans cells.
    J Gen Virol. 1995 Jun;76 ( Pt 6):1317-25 PMID: 7782762
  60. Low levels of HIV-1 infection in cutaneous dendritic cells promote extensive viral replication upon binding to memory CD4+ T cells.
    J Exp Med. 1995 Dec 1;182(6):2045-56 PMID: 7500050
  61. Sorting out the cytokines of asthma.
    J Exp Med. 1996 Jan 1;183(1):1-5 PMID: 8551212
  62. Cellular targets of infection and route of viral dissemination after an intravaginal inoculation of simian immunodeficiency virus into rhesus macaques.
    J Exp Med. 1996 Jan 1;183(1):215-25 PMID: 8551225
  63. Replication of HIV-1 in dendritic cell-derived syncytia at the mucosal surface of the adenoid.
    Science. 1996 Apr 5;272(5258):115-7 PMID: 8600520
  64. HIV-1 entry cofactor: functional cDNA cloning of a seven-transmembrane, G protein-coupled receptor.
    Science. 1996 May 10;272(5263):872-7 PMID: 8629022
  65. Cloning, expression, and characterization of the human eosinophil eotaxin receptor.
    J Exp Med. 1996 May 1;183(5):2349-54 PMID: 8642344
  66. HIV-1 Langerhans' cell tropism associated with heterosexual transmission of HIV.
    Science. 1996 Mar 1;271(5253):1291-3 PMID: 8638113
  67. Identification of a major co-receptor for primary isolates of HIV-1.
    Nature. 1996 Jun 20;381(6584):661-6 PMID: 8649511
  68. HIV-1 entry into CD4+ cells is mediated by the chemokine receptor CC-CKR-5.
    Nature. 1996 Jun 20;381(6584):667-73 PMID: 8649512
  69. The beta-chemokine receptors CCR3 and CCR5 facilitate infection by primary HIV-1 isolates.
    Cell. 1996 Jun 28;85(7):1135-48 PMID: 8674119
  70. A dual-tropic primary HIV-1 isolate that uses fusin and the beta-chemokine receptors CKR-5, CKR-3, and CKR-2b as fusion cofactors.
    Cell. 1996 Jun 28;85(7):1149-58 PMID: 8674120
  71. CC CKR5: a RANTES, MIP-1alpha, MIP-1beta receptor as a fusion cofactor for macrophage-tropic HIV-1.
    Science. 1996 Jun 28;272(5270):1955-8 PMID: 8658171
  72. The march of AIDS through Asia.
    N Engl J Med. 1996 Aug 1;335(5):343-5 PMID: 8663856
Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.71.10.8008-8013.1997
Published
1997-10-00
Pages
8008-13
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC192163
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.71.10.8008-8013.1997 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2