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PMID: 9294224 Published · ppublish English Comparative Study Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Genetic influence on neurogenesis in the dentate gyrus of adult mice.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 94 ·No. 19 ·1997-09-16 ·Pages 10409-14

Kempermann G, Kuhn HG, Gage FH

Abstract

To address genetic influences on hippocampal neurogenesis in adult mice, we compared C57BL/6, BALB/c, CD1(ICR), and 129Sv/J mice to examine proliferation, survival, and differentiation of newborn cells in the dentate gyrus. Proliferation was highest in C57BL/6; the survival rate of newborn cells was highest in CD1. In all strains approximately 60% of surviving newborn cells had a neuronal phenotype, but 129/SvJ produced more astrocytes. Over 6 days C57BL/6 produced 0.36% of their total granule cell number of 239,000 as new neurons, BALB/c 0.30% of 242,000, CD1 (ICR) 0.32% of 351,000, and 129/SvJ 0.16% of 280,000. These results show that different aspects of adult hippocampal neurogenesis are differentially influenced by the genetic background.

MeSH Terms
Animals Cell Differentiation Cell Division Cell Survival Dentate Gyrus/cytology,growth & development,metabolism Immunohistochemistry Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Inbred ICR Microscopy, Confocal Neurons/cytology Species Specificity
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Kempermann G
Laboratory of Genetics, The Salk Institute for Biological Studies, 10010 North Torrey Pines Road, La Jolla, CA 92037, USA.
Kuhn H G
Gage F H
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.94.19.10409
Published
1997-09-16
Pages
10409-14
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC23376
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.94.19.10409 PMC Full Text View journal details
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