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PMID: 9275221 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

A secreted Salmonella protein with homology to an avirulence determinant of plant pathogenic bacteria.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 94 ·No. 18 ·1997-09-02 ·Pages 9887-92

Hardt WD, Galán JE

Abstract

Bacterial pathogens have evolved sophisticated mechanisms to interact with their hosts. A specialized type III protein secretion system capable of translocating bacterial proteins into host cells has emerged as a central factor in the interaction between a variety of mammalian and plant pathogenic bacteria with their hosts. Here we describe AvrA, a novel target of the centisome 63 type III protein secretion system of Salmonella enterica. AvrA shares sequence similarity with YopJ of the animal pathogen Yersinia pseudotuberculosis and AvrRxv of the plant pathogen Xanthomonas campestris pv. vesicatoria. These proteins are the first examples of putative targets of type III secretion systems in animal and plant pathogenic bacteria that share sequence similarity. They may therefore constitute a novel family of effector proteins with related functions in the cross-talk of these pathogens with their hosts.

MeSH Terms
Amino Acid Sequence Bacterial Proteins/genetics,metabolism Molecular Sequence Data Plants/microbiology Salmonella/metabolism Sequence Alignment Sequence Analysis Sequence Homology, Amino Acid
Chemicals
Bacterial Proteins
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Hardt W D
Department of Molecular Genetics and Microbiology, State University of New York at Stony Brook, Stony Brook, NY 11794-5222, USA.
Galán J E
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.94.18.9887
Published
1997-09-02
Pages
9887-92
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC23287
Subset
IM
Grants
NIAID NIH HHS · R01 AI030492 · United States
NIAID NIH HHS · R37 AI030492 · United States
NIAID NIH HHS · AI30492 · United States
NIGMS NIH HHS · GM52543 · United States
Databases
GENBANK
AF013573, AF013574, AF013575
External Links
PubMed source DOI: 10.1073/pnas.94.18.9887 PMC Full Text View journal details
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