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PMID: 921262 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

Metabolism of naphthalene by Cunninghamella elegans.

Applied and environmental microbiology ·Vol. 34 ·No. 4 ·1977-10-00 ·Pages 363-70

Cerniglia CE, Gibson DT

Abstract

Cunninghamella elegans grown on Sabouraud dextrose broth in the presence of naphthalene produced six metabolites. Each product was isolated and identified by conventional chemical techniques. The major metabolites were 1-naphthol (67.9%) and 4-hydroxy-1-tetralone (16.7%). Minor products isolated were 1,4-naphthoquinone (2.8%), 1,2-naphthoquinone (0.2%), 2-naphthol (6.3%), and trans-1,2-dihydroxy-1,2-dihydronaphthalene (5.3%). C. elegans oxidized both 1-naphthol and 1,4-naphthoquinone to 4-hydroxy-1-tetralone. The results suggest that C. elegans oxidizes naphthalene by a sequence of reactions similar to those reported for the mammalian metabolism of this hydrocarbon.

MeSH Terms
Chemical Phenomena Chemistry Fungi/metabolism Mucorales/metabolism Naphthalenes/metabolism Naphthols/metabolism Naphthoquinones/metabolism Oxidation-Reduction
Chemicals
Naphthalenes Naphthols Naphthoquinones
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Cerniglia C E
Gibson D T
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32 references, click to expand
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Article Info
Journal
Applied and environmental microbiology
Abbr.
Appl Environ Microbiol
ISSN
0099-2240
DOI
10.1128/aem.34.4.363-370.1977
Published
1977-10-00
Pages
363-70
Language
English
Region
United States
NLM ID
7605801
PMCID
PMC242664
Subset
IM
External Links
PubMed source DOI: 10.1128/aem.34.4.363-370.1977 PMC Full Text View journal details
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