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PMID: 9170099 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S. Review

The effects of interferon-gamma on the central nervous system.

Molecular neurobiology ·Vol. 14 ·No. 1-2 ·1997-00-00 ·Pages 19-35

Popko B, Corbin JG, Baerwald KD, Dupree J, Garcia AM

Abstract

Interferon-gamma (IFN-gamma) is a pleotropic cytokine released by T-lymphocytes and natural killer cells. Normally, these cells do not traverse the blood-brain barrier at appreciable levels and, as such, IFN-gamma is generally undetectable within the central nervous system (CNS). Nevertheless, in response to CNS infections, as well as during certain disorders in which the CNS is affected, T-cell traffic across the blood-brain barrier increases considerably, thereby exposing neuronal and glial cells to the potent effects of IFN-gamma. A larger portion of this article is devoted to the substantial circumstantial and experimental evidence that suggests that IFN-gamma plays an important role in the pathogenesis of the demyelinating disorder multiple sclerosis (MS) and its animal model experimental allergic encephalomyelitis (EAE). Moreover, the biochemical and physiological effects of IFN-gamma are discussed in the context of the potential consequences of such activities on the developing and mature nervous systems.

MeSH Terms
Animals Astrocytes/physiology Central Nervous System/drug effects,physiology Encephalomyelitis, Autoimmune, Experimental/physiopathology Humans Interferon-gamma/pharmacology,physiology Multiple Sclerosis/physiopathology Neurons/physiology
Chemicals
Interferon-gamma
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Popko B
Department of Biochemistry, UNC Neuroscience Center, University of North Carolina, Chapel Hill 27599-7250, USA.
Corbin J G
Baerwald K D
Dupree J
Garcia A M
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Article Info
Journal
Molecular neurobiology
Abbr.
Mol Neurobiol
ISSN
0893-7648
DOI
10.1007/BF02740619
Published
1997-00-00
Pages
19-35
Language
English
Region
United States
NLM ID
8900963
PMCID
PMC7091409
Subset
IM
Grants
NICHD NIH HHS · HD07201 · United States
NINDS NIH HHS · NS 01637 · United States
NINDS NIH HHS · R0I NS34939 · United States
External Links
PubMed source DOI: 10.1007/BF02740619 PMC Full Text View journal details
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