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PMID: 1697609 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Autoreactive T lymphocytes in multiple sclerosis determined by antigen-induced secretion of interferon-gamma.

The Journal of clinical investigation ·Vol. 86 ·No. 3 ·1990-09-00 ·Pages 981-5

Olsson T, Zhi WW, Höjeberg B, Kostulas V, Jiang YP, Anderson G, Ekre HP, Link H

Abstract

Multiple sclerosis (MS) is a disease with unknown cause characterized by inflammation and demyelination in the central nervous system. Although an autoimmune pathogenesis has been suggested, there are no conclusive data on the number of T cells autoreactive with myelin antigens in MS compared to controls. We showed that T lymphocytes secreting interferon-gamma in response to possible target autoantigens are severalfold more common among PBL mononuclear cells in patients with MS than in patients with aseptic meningitis and tension headache. On average T cells reactive with myelin basic protein (MBP), two different MBP peptides, or with proteolipid protein amounted to 2.7-5.2/10(5) PBL from MS patients. MBP-reactive T cells were still more frequent among mononuclear cells isolated from the cerebrospinal fluid (CSF; 185/10(5) CSF cells). We concluded that T cells reactive with myelin autoantigens are strongly increased in MS. This approach to detect them could allow definition of immunodominant T cell epitopes in individual MS patients, and thereby enable further development towards specific immunotherapy.

MeSH Terms
Adult Aged Autoantigens/immunology Autoimmune Diseases/immunology Cerebrospinal Fluid/cytology Humans Interferon-gamma/biosynthesis Middle Aged Multiple Sclerosis/immunology Myelin Basic Protein/immunology Myelin Proteins/immunology Myelin Proteolipid Protein T-Lymphocytes/immunology
Chemicals
Autoantigens Myelin Basic Protein Myelin Proteins Myelin Proteolipid Protein Interferon-gamma
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Olsson T
Department of Neurology, Karolinska Institutet, Huddinge University Hospital, Sweden.
Zhi W W
Höjeberg B
Kostulas V
Jiang Y P
Anderson G
Ekre H P
Link H
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Article Info
Journal
The Journal of clinical investigation
Abbr.
J Clin Invest
ISSN
0021-9738
DOI
10.1172/JCI114800
Published
1990-09-00
Pages
981-5
Language
English
Region
United States
NLM ID
7802877
PMCID
PMC296818
Subset
IM
External Links
PubMed source DOI: 10.1172/JCI114800 PMC Full Text View journal details
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