Home LiteratureArticle Details
PMID: 9116756 Published · ppublish English Journal Article Review

The E-cadherin cell-cell adhesion pathway in urologic malignancies.

World journal of urology ·Vol. 13 ·No. 6 ·1995-00-00 ·Pages 364-8

Morton RA, Ewing CM, Watkins JJ, Isaacs WB

Abstract

Alterations in the E-cadherin-mediated cell-cell adhesion pathway are commonly observed in urologic malignancies. This issue has been addressed most thoroughly in prostate cancer. Whereas both cadherin and catenin dysfunction have been seen in human prostate cancers, only down-regulation of E-cadherin has been shown for bladder cancer and renal-cell carcinoma. Although studies in bladder cancer and renal-cell carcinoma are less mature than studies in prostate cancer, they support the hypothesis that immunostaining for E-cadherin may be of significance for both diagnostic and prognostic purposes. Finally, the E-cadherin-mediated cell-cell adhesion pathway may represent a novel chemotherapeutic target for bladder cancer, prostate cancer, and renal-cell carcinoma. Obviously, more work lies ahead to translate these important observations from the bench to the bedside.

MeSH Terms
Cadherins/chemistry,physiology Carcinoma, Renal Cell/physiopathology Cell Communication/physiology Humans Kidney Neoplasms/physiopathology Male Neoplasm Invasiveness Prostatic Neoplasms/physiopathology Structure-Activity Relationship Urinary Bladder Neoplasms/physiopathology Urologic Neoplasms/physiopathology,therapy
Chemicals
Cadherins
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Morton R A
Scott Department of Urology, Baylor College of Medicine, Houston, TX, USA.
Ewing C M
Watkins J J
Isaacs W B
References (52)
52 references, click to expand
  1. E-cadherin gene mutations provide clues to diffuse type gastric carcinomas.
    Cancer Res. 1994 Jul 15;54(14):3845-52 PMID: 8033105
  2. Genetic manipulation of E-cadherin expression by epithelial tumor cells reveals an invasion suppressor role.
    Cell. 1991 Jul 12;66(1):107-19 PMID: 2070412
  3. Molecular organization of the uvomorulin-catenin complex.
    J Cell Biol. 1992 Feb;116(4):989-96 PMID: 1734027
  4. The uvomorulin-anchorage protein alpha catenin is a vinculin homologue.
    Proc Natl Acad Sci U S A. 1991 Oct 15;88(20):9156-60 PMID: 1924379
  5. Assignment of the human alpha-catenin gene (CTNNA1) to chromosome 5q21-q22.
    Genomics. 1994 Jan 1;19(1):188-90 PMID: 8188230
  6. Phylogenetic analysis of the cadherin superfamily.
    Bioessays. 1992 Nov;14(11):743-8 PMID: 1365887
  7. Regulation of embryonic cell adhesion by the cadherin cytoplasmic domain.
    Cell. 1992 Apr 17;69(2):225-36 PMID: 1568244
  8. Association of the APC tumor suppressor protein with catenins.
    Science. 1993 Dec 10;262(5140):1734-7 PMID: 8259519
  9. Wnt-1 modulates cell-cell adhesion in mammalian cells by stabilizing beta-catenin binding to the cell adhesion protein cadherin.
    J Cell Biol. 1994 Mar;124(5):729-41 PMID: 8120095
  10. Identification of a neural alpha-catenin as a key regulator of cadherin function and multicellular organization.
    Cell. 1992 Jul 24;70(2):293-301 PMID: 1638632
  11. The structural and functional analysis of cadherin calcium-dependent cell adhesion molecules.
    Curr Opin Cell Biol. 1993 Oct;5(5):797-805 PMID: 8240823
  12. Allelotyping of human prostatic adenocarcinoma.
    Genomics. 1991 Nov;11(3):530-6 PMID: 1685474
  13. Immunohistochemical evaluation of alpha-catenin expression in human gastric cancer.
    Virchows Arch. 1994;424(4):375-81 PMID: 8205352
  14. Cadherin intercellular adhesion molecule in hepatocellular carcinomas: loss of E-cadherin expression in an undifferentiated carcinoma.
    Cancer Lett. 1991 May 1;57(2):131-5 PMID: 1851053
  15. Inverse relation of E-cadherin and autocrine motility factor receptor expression as a prognostic factor in patients with bladder carcinomas.
    Cancer Res. 1994 Jun 15;54(12 ):3120-3 PMID: 8205527
  16. Prevention of breast cancer in the rat with 9-cis-retinoic acid as a single agent and in combination with tamoxifen.
    Cancer Res. 1994 Sep 1;54(17):4614-7 PMID: 8062253
  17. Reduction of E-cadherin levels and deletion of the alpha-catenin gene in human prostate cancer cells.
    Cancer Res. 1993 Aug 1;53(15):3585-90 PMID: 8339265
  18. The 102 kd cadherin-associated protein: similarity to vinculin and posttranscriptional regulation of expression.
    Cell. 1991 May 31;65(5):849-57 PMID: 1904011
  19. Association of the APC gene product with beta-catenin.
    Science. 1993 Dec 10;262(5140):1731-4 PMID: 8259518
  20. Dynamics of cadherin/catenin complex formation: novel protein interactions and pathways of complex assembly.
    J Cell Biol. 1994 Jun;125(6):1327-40 PMID: 8207061
  21. Tamoxifen restores the E-cadherin function in human breast cancer MCF-7/6 cells and suppresses their invasive phenotype.
    Cancer Res. 1994 Sep 1;54(17 ):4607-9 PMID: 8062251
  22. Mutations of the E-cadherin gene in human gynecologic cancers.
    Nat Genet. 1994 May;7(1):98-102 PMID: 8075649
  23. Decreased expression of E-cadherin in the progression of rat prostatic cancer.
    Cancer Res. 1992 May 15;52(10):2916-22 PMID: 1581909
  24. Immunohistochemical localization of cell adhesion molecule epithelial cadherin in human arachnoid villi and meningiomas.
    Cancer Res. 1992 Apr 1;52(7):1981-7 PMID: 1551127
  25. The cadherins: cell-cell adhesion molecules controlling animal morphogenesis.
    Development. 1988 Apr;102(4):639-55 PMID: 3048970
  26. E-cadherin and APC compete for the interaction with beta-catenin and the cytoskeleton.
    J Cell Biol. 1994 Dec;127(6 Pt 2):2061-9 PMID: 7806582
  27. The human protooncogene ret: a communicative cadherin?
    Trends Biochem Sci. 1992 Nov;17(11):468-9 PMID: 1455518
  28. The E-cadherin promoter: functional analysis of a G.C-rich region and an epithelial cell-specific palindromic regulatory element.
    Proc Natl Acad Sci U S A. 1991 Dec 15;88(24):11495-9 PMID: 1763063
  29. Decreased E-cadherin expression is associated with poor prognosis in patients with prostate cancer.
    Cancer Res. 1994 Jul 15;54(14):3929-33 PMID: 7518346
  30. Cadherin dysfunction in a human cancer cell line: possible involvement of loss of alpha-catenin expression in reduced cell-cell adhesiveness.
    Cancer Res. 1992 Oct 15;52(20):5770-4 PMID: 1394201
  31. Allelic loss of chromosomes 16q and 10q in human prostate cancer.
    Proc Natl Acad Sci U S A. 1990 Nov;87(22):8751-5 PMID: 1978938
  32. Regional assignment of the human loci for uvomorulin (UVO) and chymotrypsinogen B (CTRB) with the help of two overlapping deletions on the long arm of chromosome 16.
    Cytogenet Cell Genet. 1989;50(2-3):145-8 PMID: 2789125
  33. Characterization of antigens recognized by monoclonal and polyclonal antibodies directed against uvomorulin.
    Proc Natl Acad Sci U S A. 1985 Dec;82(23):8067-71 PMID: 2415979
  34. E-cadherin expression in colorectal cancer. An immunocytochemical and in situ hybridization study.
    Am J Pathol. 1993 Apr;142(4):981-6 PMID: 7682766
  35. Loss of epithelial differentiation and gain of invasiveness correlates with tyrosine phosphorylation of the E-cadherin/beta-catenin complex in cells transformed with a temperature-sensitive v-SRC gene.
    J Cell Biol. 1993 Feb;120(3):757-66 PMID: 8425900
  36. Cell-cell contacts mediated by E-cadherin (uvomorulin) restrict invasive behavior of L-cells.
    J Cell Biol. 1991 Jul;114(2):319-27 PMID: 1649199
  37. Expression of cell adhesion molecules alpha-2, alpha-5 and alpha-6 integrin, E-cadherin, N-CAM and CD-44 in renal cell carcinomas. An immunohistochemical study.
    Virchows Arch A Pathol Anat Histopathol. 1993;422(3):219-24 PMID: 8493778
  38. Expression of the cellular adhesion molecule E-cadherin is reduced or absent in high-grade prostate cancer.
    Cancer Res. 1992 Sep 15;52(18):5104-9 PMID: 1516067
  39. Expression of E-cadherin in normal, benign, and malignant tissues of female genital organs.
    Am J Clin Pathol. 1992 Jul;98(1):76-80 PMID: 1615930
  40. E-cadherin and alpha-catenin expression in human esophageal cancer.
    Cancer Res. 1994 Jan 1;54(1):291-6 PMID: 8261454
  41. A truncated beta-catenin disrupts the interaction between E-cadherin and alpha-catenin: a cause of loss of intercellular adhesiveness in human cancer cell lines.
    Cancer Res. 1994 Dec 1;54(23):6282-7 PMID: 7954478
  42. Structure, expression and chromosome assignment of the human catenin (cadherin-associated protein) alpha 1 gene (CTNNA1).
    Cytogenet Cell Genet. 1994;65(1-2):74-8 PMID: 8404069
  43. E-cadherin gene mutations in human gastric carcinoma cell lines.
    Proc Natl Acad Sci U S A. 1994 Mar 1;91(5):1858-62 PMID: 8127895
  44. Expression of E-cadherin cell adhesion molecules in human breast cancer tissues and its relationship to metastasis.
    Cancer Res. 1993 Apr 1;53(7):1696-701 PMID: 8453644
  45. Transcriptional regulation of the human E-cadherin gene in human prostate cancer cell lines: characterization of the human E-cadherin gene promoter.
    Biochem Biophys Res Commun. 1994 Sep 15;203(2):1284-90 PMID: 8093045
  46. Uvomorulin-catenin complex formation is regulated by a specific domain in the cytoplasmic region of the cell adhesion molecule.
    Proc Natl Acad Sci U S A. 1990 Jun;87(11):4246-50 PMID: 2349235
  47. From cadherins to catenins: cytoplasmic protein interactions and regulation of cell adhesion.
    Trends Genet. 1993 Sep;9(9):317-21 PMID: 8236461
  48. The cytoplasmic domain of the cell adhesion molecule uvomorulin associates with three independent proteins structurally related in different species.
    EMBO J. 1989 Jun;8(6):1711-7 PMID: 2788574
  49. Alterations in beta-catenin phosphorylation and plakoglobin expression in human breast cancer cells.
    Cancer Res. 1994 Jul 1;54(13):3544-52 PMID: 8012979
  50. E-cadherin-mediated cell-cell adhesion prevents invasiveness of human carcinoma cells.
    J Cell Biol. 1991 Apr;113(1):173-85 PMID: 2007622
  51. Cell binding function of E-cadherin is regulated by the cytoplasmic domain.
    EMBO J. 1988 Dec 1;7(12):3679-84 PMID: 3061804
  52. Decreased E-cadherin immunoreactivity correlates with poor survival in patients with bladder tumors.
    Cancer Res. 1993 Jul 15;53(14):3241-5 PMID: 8324734
Article Info
Journal
World journal of urology
Abbr.
World J Urol
ISSN
0724-4983
DOI
10.1007/BF00191218
Published
1995-00-00
Pages
364-8
Language
English
Region
Germany
NLM ID
8307716
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00191218 View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2