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PMID: 8988395 Published · ppublish English Journal Article Review

Peptide selection for presentation by HLA class I: a role for the human transporter associated with antigen processing?

Immunologic research ·Vol. 15 ·No. 4 ·1996-00-00 ·Pages 265-79

van Endert PM

Abstract

Peptide epitopes presented by HLA class I are supplied by an elaborate system of antigen processing which subjects candidate epitopes to a process of selection according to little-understood rules. Transport of peptides from the cytosol into the endoplasmic reticulum by the TAP (transporter associated with antigen processing) complex is likely to play an important role in peptide selection for presentation. The recent development of an assay measuring substrate binding to the TAP complex has led to the identification of the major structural properties of peptides selected by the human transporter. Human TAP favors transport of peptides with structural features common to HLA class I ligands. However, TAP dislikes peptide ligands preferred by some HLA class I alleles, which may therefore frequently rely on alternative sources of peptide ligands.

MeSH Terms
ATP-Binding Cassette Transporters/metabolism Antigen Presentation HLA Antigens/metabolism Histocompatibility Antigens Class I/metabolism Humans Peptides/immunology
Chemicals
ATP-Binding Cassette Transporters HLA Antigens Histocompatibility Antigens Class I Peptides
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
van Endert P M
INSERM U25, Hôpital Necker, Paris, France.
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34 references, click to expand
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Article Info
Journal
Immunologic research
Abbr.
Immunol Res
ISSN
0257-277X
DOI
10.1007/BF02935312
Published
1996-00-00
Pages
265-79
Language
English
Region
United States
NLM ID
8611087
Subset
IM
External Links
PubMed source DOI: 10.1007/BF02935312 View journal details
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