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PMID: 8988253 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Review

Mitochondrial distribution and inheritance.

Experientia ·Vol. 52 ·No. 12 ·1996-12-15 ·Pages 1111-6

Berger KH, Yaffe MP

Abstract

Mechanisms mediating the inheritance of mitochondria are poorly understood, but recent studies with the yeasts Saccharomyces cerevisiae and Schizosaccharomyces pombe have begun to identify components that facilitate this essential process. These components have been identified through the analysis of conditional yeast mutants that display aberrant mitochondrial distribution at restrictive conditions. The analysis of these mutants has uncovered several novel proteins that are localized either to cytoskeletal structures or to the mitochondria themselves. Many mitochondrial inheritance mutants also show altered mitochondrial morphology and defects in maintenance of the mitochondrial genome. Although some inheritance components and mechanisms appear to function specifically in certain types of cells, other conserved proteins are likely to mediate mitochondrial behavior in all eukaryotic cells.

MeSH Terms
Cell Membrane/chemistry,metabolism Cytoskeleton/chemistry,metabolism Mitochondria/chemistry,genetics,metabolism Mitosis/genetics Models, Biological Mutation/genetics Saccharomyces/genetics
Authors & Affiliations
2 authors, click to expand affiliations / ORCID
Berger K H
Department of Biology, University of California, San Diego, La Jolla 92093-0347, USA.
Yaffe M P
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Article Info
Journal
Experientia
Abbr.
Experientia
ISSN
0014-4754
DOI
10.1007/BF01952109
Published
1996-12-15
Pages
1111-6
Language
English
Region
Switzerland
NLM ID
0376547
Subset
IM
Grants
NIGMS NIH HHS · GM44614 · United States
External Links
PubMed source DOI: 10.1007/BF01952109
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