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PMID: 8942956 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S. Review

A synaptic basis for memory storage in the cerebral cortex.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 93 ·No. 24 ·1996-11-26 ·Pages 13453-9

Bear MF

Abstract

A cardinal feature of neurons in the cerebral cortex is stimulus selectivity, and experience-dependent shifts in selectivity are a common correlate of memory formation. We have used a theoretical "learning rule," devised to account for experience-dependent shifts in neuronal selectivity, to guide experiments on the elementary mechanisms of synaptic plasticity in hippocampus and neocortex. These experiments reveal that many synapses in hippocampus and neocortex are bidirectionally modifiable, that the modifications persist long enough to contribute to long-term memory storage, and that key variables governing the sign of synaptic plasticity are the amount of NMDA receptor activation and the recent history of cortical activity.

MeSH Terms
Animals Axons/physiology Cerebral Cortex/physiology Learning/physiology Long-Term Potentiation Memory/physiology Models, Neurological Neuronal Plasticity Neurons/physiology Receptors, N-Methyl-D-Aspartate/physiology Synapses/physiology Visual Cortex/physiology
Chemicals
Receptors, N-Methyl-D-Aspartate
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Bear M F
Department of Neuroscience, Brown University, Providence, RI 02912, USA.
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.93.24.13453
Published
1996-11-26
Pages
13453-9
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC33630
Subset
IM
External Links
PubMed source DOI: 10.1073/pnas.93.24.13453 PMC Full Text View journal details
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