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PMID: 3460096 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Hebbian synapses in hippocampus.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 83 ·No. 14 ·1986-07-00 ·Pages 5326-30

Kelso SR, Ganong AH, Brown TH

Abstract

A combination of current- and voltage-clamp techniques applied to hippocampal brain slices was used to evaluate the role of postsynaptic electrogenesis in the induction of associative synaptic enhancement. In accordance with Hebb's postulate for learning, repetitive postsynaptic spiking enabled enhancement in just those synapses that were eligible to change by virtue of concurrent presynaptic activity. However, the essential postsynaptic electrogenic event that controlled the enhancement was shown to involve biophysical processes that were unknown when Hebb formulated his neurophysiological postulate. The demonstrated spatiotemporal specificity of this pseudo-Hebbian conjunctive mechanism can account qualitatively for the known neurophysiological properties of associative long-term potentiation in these synapses, which in turn can explain the "cooperativity" requirement for long-term potentiation.

MeSH Terms

Animals Electric Stimulation Hippocampus/physiology Male Membrane Potentials Models, Neurological Rats Rats, Inbred Strains Sodium/physiology Synapses/physiology Time Factors

Chemicals

Sodium

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Kelso S R

Ganong A H

Brown T H

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25 references, click to expand

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Article Info

Journal

Proceedings of the National Academy of Sciences of the United States of America

Abbr.

Proc Natl Acad Sci U S A

ISSN

0027-8424

DOI

10.1073/pnas.83.14.5326

Published

1986-07-00

Pages

5326-30

Language

English

Region

United States

NLM ID

7505876

PMCID

PMC323944

Subset

Grants

NINDS NIH HHS · NS07408 · United States

External Links

PubMed source DOI: 10.1073/pnas.83.14.5326 PMC Full Text View journal details

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Hebbian synapses in hippocampus.

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