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PMID: 885534 Published · ppublish English Journal Article

Localization of HLA on the short arm of chromosome 6.

Human genetics ·Vol. 37 ·No. 2 ·1977-06-30 ·Pages 131-9

Breuning MH, van den Berg-Loonen EM, Bernini LF, Bijlsma JB, van Loghem E, Meera Khan P, Nijenhuis LE

Abstract

A detailed marker gene study in a large Dutch kindred segregating for a reciprocal translocation between the chromosomes 6 and 20, t(6;20) (p21; p13), revealed a close linkage between the HLA genes and the breakpoint on the short arm of 6. During this study an apparent peak lod score of 2.9 was obtained at a recombination value of 0.05 for a linkage between HLA and the breakpoint, indicating that the chromosomal region, carrying the HLA genes, is situated near the breakpoint in band 6p21 close to the transition to 6p22.

MeSH Terms
Abnormalities, Multiple/genetics Chromosome Mapping Chromosomes, Human, 19-20 Chromosomes, Human, 6-12 and X Female Genetic Linkage HLA Antigens Histocompatibility Antigens Humans Infant Male Netherlands Pedigree Recombination, Genetic Translocation, Genetic
Chemicals
HLA Antigens Histocompatibility Antigens
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Breuning M H
van den Berg-Loonen E M
Bernini L F
Bijlsma J B
van Loghem E
Meera Khan P
Nijenhuis L E
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Article Info
Journal
Human genetics
Abbr.
Hum Genet
ISSN
0340-6717
DOI
10.1007/BF00393575
Published
1977-06-30
Pages
131-9
Language
English
Region
Germany
NLM ID
7613873
Subset
IM
External Links
PubMed source DOI: 10.1007/BF00393575 View journal details
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