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PMID: 8846904 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

Centromere-linkage analysis and consolidation of the zebrafish genetic map.

Genetics ·Vol. 142 ·No. 4 ·1996-04-00 ·Pages 1277-88

Johnson SL, Gates MA, Johnson M, Talbot WS, Horne S, Baik K, Rude S, Wong JR, Postlethwait JH

Abstract

The ease of isolating mutations in zebrafish will contribute to an understanding of a variety of processes common to all vertebrates. To facilitate genetic analysis of such mutations, we have identified DNA polymorphisms closely linked to each of the 25 centromeres of zebrafish, placed centromeres on the linkage map, increased the number of mapped PCR-based markers to 652, and consolidated the number of linkage groups to the number of chromosomes. This work makes possible centromere-linkage analysis, a novel, rapid method to assign mutations to a specific linkage group using half-tetrads.

MeSH Terms
Animals Base Sequence Centromere Chromosome Mapping DNA Primers Genetic Linkage Genetic Markers Molecular Sequence Data Polymorphism, Genetic Zebrafish/genetics
Chemicals
DNA Primers Genetic Markers
Authors & Affiliations
9 authors, click to expand affiliations / ORCID
Johnson S L
Institute of Neuroscience, University of Oregon, Eugene 97403, USA. sjohnson@uoneuro.uoregon.edu
Gates M A
Johnson M
Talbot W S
Horne S
Baik K
Rude S
Wong J R
Postlethwait J H
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Article Info
Journal
Genetics
Abbr.
Genetics
ISSN
0016-6731
DOI
10.1093/genetics/142.4.1277
Email
sjohnson@uoneuro.uoregon.edu
Published
1996-04-00
Pages
1277-88
Language
English
Region
United States
NLM ID
0374636
PMCID
PMC1207124
Subset
IM
Grants
NICHD NIH HHS · 1PO1HD-22486 · United States
NIAID NIH HHS · 1RO1AI-26734 · United States
NICHD NIH HHS · HD-07470 · United States
External Links
PubMed source DOI: 10.1093/genetics/142.4.1277 PMC Full Text View journal details
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