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PMID: 8824643 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

The mitogen-activated protein kinase homolog HOG1 gene controls glycerol accumulation in the pathogenic fungus Candida albicans.

Journal of bacteriology ·Vol. 178 ·No. 19 ·1996-10-00 ·Pages 5850-2

San José C, Monge RA, Pérez-Díaz R, Pla J, Nombela C

Abstract

The Candida albicans HOG1 gene (HOG1CA) was cloned by functional complementation of the osmosensitive phenotype associated with Saccharomyces cerevisiae hog1 delta mutants. HOG1CA codes for a 377-amino-acid protein, 78% identical to S. cerevisiae Hog1p. A C. albicans hog1 null mutant was found to be sensitive to osmotic stress and failed to accumulate glycerol on high-osmolarity media.

MeSH Terms
Adaptation, Physiological/genetics Calcium-Calmodulin-Dependent Protein Kinases/genetics Candida albicans/genetics Cloning, Molecular Genes, Fungal Genetic Complementation Test Glycerol/metabolism Mitogen-Activated Protein Kinases Molecular Sequence Data Mutagenesis, Insertional Osmotic Pressure Phenotype Saccharomyces cerevisiae Proteins Sequence Analysis, DNA Signal Transduction/genetics
Chemicals
Saccharomyces cerevisiae Proteins Calcium-Calmodulin-Dependent Protein Kinases HOG1 protein, S cerevisiae Mitogen-Activated Protein Kinases Glycerol
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
San José C
Departamento de Microbiología II, Facultad de Farmacia, Universidad Complutense de Madrid, Spain.
Monge R A
Pérez-Díaz R
Pla J
Nombela C
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19 references, click to expand
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/jb.178.19.5850-5852.1996
Published
1996-10-00
Pages
5850-2
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC178437
Subset
IM
Databases
GENBANK
X90586
External Links
PubMed source DOI: 10.1128/jb.178.19.5850-5852.1996 PMC Full Text View journal details
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