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PMID: 8557102 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Stress signal, mediated by a Hog1-like MAP kinase, controls sexual development in fission yeast.

FEBS letters ·Vol. 378 ·No. 3 ·1996-01-15 ·Pages 207-12

Kato T, Okazaki K, Murakami H, Stettler S, Fantes PA, Okayama H

Abstract

We identified the phh1+ gene that encodes a MAP kinase as the effector of Wis1 MAP kinase kinase in fission yeast, which is highly homologous with HOG1 of S. cerevisiae. Heterothalic phh1 dsiruptant is phenotypically indistinguishable from wis1 deletion mutant, both displaying the same extent of partial sterility and enhanced sensitivity to a variety of stress. In phh1 disruptant, nitrogen starvation-induced expression of ste11+, a key controller of sexual differentiation, is markedly diminished. Ectopic expression of ste11+ effectively restores fertility, but not stress resistance, to the phh1 disruptant. These data show that stress signal, mediated by a MAP kinase, is required for efficient start of sexual differentiation.

MeSH Terms

Amino Acid Sequence Base Sequence Calcium-Calmodulin-Dependent Protein Kinases/chemistry,metabolism Cell Division Culture Media/chemistry Fertility/genetics Fungal Proteins/genetics Gene Expression Regulation, Fungal Hot Temperature MAP Kinase Kinase Kinases/genetics Mitogen-Activated Protein Kinase Kinases Mitogen-Activated Protein Kinases Molecular Sequence Data Nitrogen/chemistry,metabolism Osmotic Pressure Protein Serine-Threonine Kinases/metabolism Saccharomyces cerevisiae/enzymology Saccharomyces cerevisiae Proteins Schizosaccharomyces/enzymology,physiology Schizosaccharomyces pombe Proteins Sequence Homology, Amino Acid Sex Differentiation Signal Transduction/genetics,physiology Spores Stress, Physiological Transcription Factors

Chemicals

Culture Media Fungal Proteins Saccharomyces cerevisiae Proteins Schizosaccharomyces pombe Proteins Transcription Factors ste11 protein, S pombe Protein Serine-Threonine Kinases Calcium-Calmodulin-Dependent Protein Kinases HOG1 protein, S cerevisiae Mitogen-Activated Protein Kinases MAP Kinase Kinase Kinases Ste11 protein, S cerevisiae Mitogen-Activated Protein Kinase Kinases wis1 protein, S pombe Nitrogen

Authors & Affiliations

6 authors, click to expand affiliations / ORCID

Kato T

Okayama Cell Switching Project, ERATO, JRDC, Kyoto, Japan.

Okazaki K

Murakami H

Stettler S

Fantes P A

Okayama H

Article Info

Journal

FEBS letters

Abbr.

FEBS Lett

ISSN

0014-5793

DOI

10.1016/0014-5793(95)01442-x

Published

1996-01-15

Pages

207-12

Language

English

Region

England

NLM ID

0155157

Subset

External Links

PubMed source DOI: 10.1016/0014-5793(95)01442-x View journal details

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Stress signal, mediated by a Hog1-like MAP kinase, controls sexual development in fission yeast.

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