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PMID: 8816802 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Origins of immunity: Relish, a compound Rel-like gene in the antibacterial defense of Drosophila.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 93 ·No. 19 ·1996-09-17 ·Pages 10343-7

Dushay MS, Asling B, Hultmark D

Abstract

NF-kappa B/Rel transcription factors are central regulators of mammalian immunity and are also implicated in the induction of cecropins and other antibacterial peptides in insects. We identified the gene for Relish, a compound Drosophila protein that, like mammalian p105 and p100, contains both a Rel homology domain and an I kappa B-like domain. Relish is strongly induced in infected flies, and it can activate transcription from the Cecropin A1 promoter. A Relish transcript is also detected in early embryos, suggesting that it acts in both immunity and embryogenesis. The presence of a compound Rel protein in Drosophila indicates that similar proteins were likely present in primordial immune systems and may serve unique signaling functions.

MeSH Terms
Amino Acid Sequence Animals Anti-Bacterial Agents Base Sequence Chromosome Mapping DNA Primers Drosophila Proteins Drosophila melanogaster/genetics,immunology Enterobacter cloacae/immunology Female Genes, Insect Humans Male Molecular Sequence Data NF-kappa B/genetics Phylogeny Polymerase Chain Reaction Proto-Oncogene Proteins/genetics Proto-Oncogene Proteins c-rel Repetitive Sequences, Nucleic Acid Restriction Mapping Sequence Homology, Amino Acid Transcription Factors/biosynthesis,chemistry,genetics Transfection
Chemicals
Anti-Bacterial Agents DNA Primers Drosophila Proteins NF-kappa B Proto-Oncogene Proteins Proto-Oncogene Proteins c-rel Rel protein, Drosophila Transcription Factors
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Dushay M S
Department of Developmental Biology, Stockholm University, Sweden.
Asling B
Hultmark D
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.93.19.10343
Published
1996-09-17
Pages
10343-7
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC38386
Subset
IM
Databases
GENBANK
L29015, U62005
SWISSPROT
P15330, P19838, Q00653, Q01201, Q04206, Q04864
External Links
PubMed source DOI: 10.1073/pnas.93.19.10343 PMC Full Text View journal details
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