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PMID: 8785049 Published · ppublish English Journal Article Research Support, U.S. Gov't, P.H.S.

A reciprocal cell-cell interaction mediated by NT-3 and neuregulins controls the early survival and development of sympathetic neuroblasts.

Neuron ·Vol. 16 ·No. 3 ·1996-03-00 ·Pages 515-27

Verdi JM, Groves AK, Fariñas I, Jones K, Marchionni MA, Reichardt LF, Anderson DJ

Abstract

Neurotrophin 3 (NT-3) can support the survival of some embryonic sympathetic neuroblasts before they become nerve growth factor dependent. We show that NT-3 is produced in vivo by nonneuronal cells neighboring embryonic sympathetic ganglia. NT-3 mRNA is produced by these nonneuronal cells in vitro and is up-regulated by platelet-derived growth factor, ciliary neurotrophic factor, and glial growth factor 2 (a neuregulin). Nonneuronal cell-conditioned medium promotes survival and induces TrkA expression in isolated sympathetic neuroblasts, and this activity is blocked by anti-NT-3 antibody. Neuroblasts also enhance NT-3 production by nonneural cells. Neuroblasts synthesize several forms of neuregulin, and antibodies to neuregulin attenuate the effect of the neuroblasts on the nonneuronal cells. These data suggest a reciprocal cell-cell interaction, in which neuroblast-derived neuregulins promote NT-3 production by neighboring nonneuronal cells, which in turn promotes neuroblast survival and further differentiation.

MeSH Terms
Animals Base Sequence Cell Differentiation Cell Survival/drug effects Cells, Cultured Mice Molecular Sequence Data Nerve Growth Factors/pharmacology Polymerase Chain Reaction RNA, Messenger/metabolism Sympathetic Nervous System/drug effects Time Factors
Chemicals
Nerve Growth Factors RNA, Messenger
Authors & Affiliations
7 authors, click to expand affiliations / ORCID
Verdi J M
Division of Biology 216-76, California Institute of Technology, Pasadena 91125, USA.
Groves A K
Fariñas I
Jones K
Marchionni M A
Reichardt L F
Anderson D J
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Article Info
Journal
Neuron
Abbr.
Neuron
ISSN
0896-6273
DOI
10.1016/s0896-6273(00)80071-9
Published
1996-03-00
Pages
515-27
Language
English
Region
United States
NLM ID
8809320
PMCID
PMC2711899
Subset
IM
Grants
NINDS NIH HHS · P01 NS016033 · United States
NINDS NIH HHS · P01 NS016033-180014 · United States
External Links
PubMed source DOI: 10.1016/s0896-6273(00)80071-9 PMC Full Text View journal details
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