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PMID: 8755567 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, P.H.S.

1,25-Dihydroxyvitamin D3 reversibly blocks the progression of relapsing encephalomyelitis, a model of multiple sclerosis.

Proceedings of the National Academy of Sciences of the United States of America ·Vol. 93 ·No. 15 ·1996-07-23 ·Pages 7861-4

Cantorna MT, Hayes CE, DeLuca HF

Abstract

Experimental autoimmune encephalomyelitis (EAE) is an autoimmune disease believed to be a model for the human disease multiple sclerosis (MS). Induced by immunizing B10.PL mice with myelin basic protein (MBP), EAE was completely prevented by the administration of 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3]. 1,25-(OH)2D3 could also prevent the progression of EAE when administered at the appearance of the first disability symptoms. Withdrawal of 1,25-(OH)2D3 resulted in a resumption of the progression of EAE. Thus, the block by 1,25-(OH)2D3 is reversible. A deficiency of vitamin D resulted in an increased susceptibility to EAE. Thus, 1,25-(OH)2D3 or its analogs are potentially important for treatment of MS.

MeSH Terms
Animals Calcitriol/analogs & derivatives,therapeutic use Disease Progression Encephalomyelitis, Autoimmune, Experimental/physiopathology,prevention & control,therapy Female Guinea Pigs Humans Male Mice Mice, Inbred Strains Multiple Sclerosis Mycobacterium tuberculosis Myelin Basic Protein/immunology Spinal Cord Time Factors Vitamin D Deficiency/physiopathology
Chemicals
Myelin Basic Protein Calcitriol
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Cantorna M T
Department of Biochemistry, University of Wisconsin, Madison 53706, USA.
Hayes C E
DeLuca H F
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Article Info
Journal
Proceedings of the National Academy of Sciences of the United States of America
Abbr.
Proc Natl Acad Sci U S A
ISSN
0027-8424
DOI
10.1073/pnas.93.15.7861
Published
1996-07-23
Pages
7861-4
Language
English
Region
United States
NLM ID
7505876
PMCID
PMC38839
Subset
IM
Grants
NIDDK NIH HHS · DK14881 · United States
NIDDK NIH HHS · DK46820 · United States
External Links
PubMed source DOI: 10.1073/pnas.93.15.7861 PMC Full Text View journal details
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