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PMID: 6310748 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

1,25-dihydroxyvitamin D3 receptors in human leukocytes.

Science (New York, N.Y.) ·Vol. 221 ·No. 4616 ·1983-09-16 ·Pages 1181-3

Provvedini DM, Tsoukas CD, Deftos LJ, Manolagas SC

Abstract

A 1,25-dihydroxyvitamin D3 receptor macromolecule was detected in peripheral mononuclear leukocytes from normal humans. This macromolecule was found to be present in monocytes but absent from normal resting peripheral B and T lymphocytes. However, it was present in established lines of malignant B, T, and non-B, non-T human lymphocytes, as well as in T and B lymphocytes obtained from normal humans and activated in vitro.

MeSH Terms

B-Lymphocytes/analysis Cell Line Humans Leukemia/analysis Leukocytes/analysis Lymphocyte Activation Monocytes/analysis Receptors, Calcitriol Receptors, Steroid/analysis T-Lymphocytes/analysis

Chemicals

Receptors, Calcitriol Receptors, Steroid

Authors & Affiliations

4 authors, click to expand affiliations / ORCID

Provvedini D M

Tsoukas C D

Deftos L J

Manolagas S C

Article Info

Journal

Science (New York, N.Y.)

Abbr.

Science

ISSN

0036-8075

DOI

10.1126/science.6310748

Published

1983-09-16

Pages

1181-3

Language

English

Region

United States

NLM ID

0404511

Subset

External Links

PubMed source DOI: 10.1126/science.6310748 View journal details

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1,25-dihydroxyvitamin D3 receptors in human leukocytes.

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