Different D end-dependent antigenic determinants are recognized by H-2-restricted cytotoxic T cells specific for influenza and Bebaru viruses.

The Journal of experimental medicine ·Vol. 150 ·No. 1 ·1979-07-01 ·Pages 166-3

Blanden RV, Müllbacher A, Ashman RB

Abstract

Two different BALB/c anti-CBA (H-2k)monoclonal antibodies that bind to Kk and Dk antigens blocked Tc cell-mediated lysis of L929 (Kk, Dk) target cells, but with quite different specificity. One antibody (30R3) powerfully blocked Kk-specific lysis mediated by alloreactive or Kk-restricted Tc cells immune to ectromelia, Sendai, or influenza viruses. The other antibody (27R9) blocked these anti-Kk Tc cells much less than 30R3, but in contrast, 27R9 blocked anti-Dk lysis much more than 30R3. Most importantly, 27R9 strongly blocked Dk-restricted anti-influenza Tc cells, but did not significantly block Dk-restricted anti-Bebaru (BEB) lysis. This result indicated that different H-2 determinants coded in the D end of H-2k were recognized by influenza-and BEB-immune Tc cells. These determinants may be carried on two different molecules coded by the H-2D and H-2L loci, but other possibilities are not yet excluded.

MeSH Terms

Animals Antibodies, Viral/immunology Arboviruses/genetics,immunology Cross Reactions Cytotoxicity, Immunologic Epitopes H-2 Antigens/genetics,immunology Isoantibodies/immunology Major Histocompatibility Complex Mice Mice, Inbred BALB C/genetics,immunology Mice, Inbred CBA/genetics,immunology Mutation Orthomyxoviridae/genetics,immunology Peptides/immunology T-Lymphocytes/immunology

Chemicals

Antibodies, Viral Epitopes H-2 Antigens Isoantibodies Peptides

Authors & Affiliations

3 authors, click to expand affiliations / ORCID

Blanden R V

Müllbacher A

Ashman R B

References (20)

20 references, click to expand

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Article Info

Journal

The Journal of experimental medicine

Abbr.

J Exp Med

ISSN

0022-1007

DOI

10.1084/jem.150.1.166

Published

1979-07-01

Pages

166-3

Language

English

Region

United States

NLM ID

2985109R

PMCID

PMC2185601

Subset

External Links

PubMed source DOI: 10.1084/jem.150.1.166 PMC Full Text View journal details

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Different D end-dependent antigenic determinants are recognized by H-2-restricted cytotoxic T cells specific for influenza and Bebaru viruses.

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