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PMID: 8666893 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Impaired neutrophil response and CD4+ T helper cell 1 development in interleukin 6-deficient mice infected with Candida albicans.

The Journal of experimental medicine ·Vol. 183 ·No. 4 ·1996-04-01 ·Pages 1345-55

Romani L, Mencacci A, Cenci E, Spaccapelo R, Toniatti C, Puccetti P, Bistoni F, Poli V

Abstract

To define the role of interleukin (IL)6 in Candida albicans infection, IL-6 deficient mice were assessed for susceptibility to systemic or gastrointestinal infection, as well as for parameters of elicited T helper cell (Th) immunity. IL-6-deficient mice were more susceptible than wild-type mice to either type of infection caused by virulent C. albicans. In response to systemic challenge with a live vaccine strain of yeast, IL-6-deficient mice failed to mount Th1-associated protective immunity, but the resulting Th2-biased response could be redirected to the Th1 phenotype by IL-10 neutralization. Severe impairment of the macrophage and neutrophil response to infection was observed in IL-6-deficient mice, but administration of IL-6 would increase both neutrophil response and resistance to infection. IL-6 seems to oppose the Th2-promoting role of IL-10 in candidiasis, its early regulatory activity involving effects on neutrophil function.

MeSH Terms
Animals Candida albicans/pathogenicity Candidiasis/immunology Cytokines/blood Disease Susceptibility Female Interleukin-10/immunology Interleukin-6/deficiency,pharmacology Kidney/pathology Lymphocyte Activation Mice Neutralization Tests Neutrophils/immunology Stomach/pathology Th1 Cells/immunology Th2 Cells/immunology
Chemicals
Cytokines Interleukin-6 Interleukin-10
Authors & Affiliations
8 authors, click to expand affiliations / ORCID
Romani L
Microbiology Section, Department of Experimental Medicine and Biomedical Sciences, University of Perugia, Italy.
Mencacci A
Cenci E
Spaccapelo R
Toniatti C
Puccetti P
Bistoni F
Poli V
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Article Info
Journal
The Journal of experimental medicine
Abbr.
J Exp Med
ISSN
0022-1007
DOI
10.1084/jem.183.4.1345
Published
1996-04-01
Pages
1345-55
Language
English
Region
United States
NLM ID
2985109R
PMCID
PMC2192497
Subset
IM
External Links
PubMed source DOI: 10.1084/jem.183.4.1345 PMC Full Text View journal details
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