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PMID: 8648694 Published · ppublish English Journal Article

The human T-cell leukemia/lymphotropic virus type 1 p12I proteins bind the interleukin-2 receptor beta and gammac chains and affects their expression on the cell surface.

Journal of virology ·Vol. 70 ·No. 6 ·1996-06-00 ·Pages 3599-605

Mulloy JC, Crownley RW, Fullen J, Leonard WJ, Franchini G

Abstract

p12I is a small hydrophobic protein encoded by the human T-cell leukemia/lymphotropic virus type 1 (HTLV-1) that interacts with the 16-kDa component of the H+ vacuolar ATPase and cooperates with bovine papillomavirus 1 E5 oncoprotein in cell transformation. Just as an important step in E5 action appears to be its binding to the platelet-derived growth factor receptor, it was found that p12I binds specifically to both the beta and gamma(c) chains of the interleukin-2 receptor (IL-2R). The IL-2R beta and gamma(c) chains associated with p12I are endoglycosidase-H sensitive, suggesting that their interaction occurs in a pre-Golgi compartment. p12I stabilizes the immature forms of the IL-2R beta and gamma(c) chains and decreases their cell surface expression. The interactions of p12I with IL-2R beta and gamma(c) may have important implications in the immunosuppressive effect of HTLV-1 in vivo as well as in the ligand-independent HTLV-1-mediated T-cell proliferation.

MeSH Terms
Golgi Apparatus/metabolism HTLV-I Infections/immunology HeLa Cells Human T-lymphotropic virus 1/chemistry Humans Receptors, Interleukin-2/analysis,metabolism Retroviridae Proteins/metabolism
Chemicals
Receptors, Interleukin-2 Retroviridae Proteins
Authors & Affiliations
5 authors, click to expand affiliations / ORCID
Mulloy J C
Laboratory of Tumor Cell Biology, National Cancer Institute, Bethesda, Maryland 20892, USA.
Crownley R W
Fullen J
Leonard W J
Franchini G
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Article Info
Journal
Journal of virology
Abbr.
J Virol
ISSN
0022-538X
DOI
10.1128/JVI.70.6.3599-3605.1996
Published
1996-06-00
Pages
3599-605
Language
English
Region
United States
NLM ID
0113724
PMCID
PMC190235
Subset
IM
External Links
PubMed source DOI: 10.1128/JVI.70.6.3599-3605.1996 PMC Full Text View journal details
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