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PMID: 856013 Published · ppublish English Journal Article Research Support, U.S. Gov't, Non-P.H.S. Research Support, U.S. Gov't, P.H.S.

Plasmid-medicated aminoglycoside phosphotransferase of broad substrate range that phosphorylates amikacin.

Antimicrobial agents and chemotherapy ·Vol. 11 ·No. 4 ·1977-04-00 ·Pages 619-24

Courvalin P, Davies J

Abstract

A plasmid-mediated aminoglycoside phosphotransferase that phosphorylates amikacin has been detected in clinical isolates of Staphylococcus aureus. This enzyme does not confer detectable amikacin resistance to the strains.

MeSH Terms

Amikacin/metabolism Aminoglycosides/metabolism Extrachromosomal Inheritance Kanamycin/analogs & derivatives Phosphotransferases/metabolism Plasmids Staphylococcus/enzymology

Chemicals

Aminoglycosides Kanamycin Amikacin Phosphotransferases

Authors & Affiliations

2 authors, click to expand affiliations / ORCID

Courvalin P

Davies J

References (9)

9 references, click to expand

Isolation and characterization of a kanamycin resistance plasmid from Staphylococcus aureus.
Antimicrob Agents Chemother. 1974 Oct;6(4):516-20 PMID: 4157356
New plasmid-mediated nucleotidylation of aminoglycoside antibiotics in Staphlococcus aureus.
Antimicrob Agents Chemother. 1976 Aug;10(2):258-64 PMID: 984767
Antibiotic susceptibility testing by a standardized single disk method.
Am J Clin Pathol. 1966 Apr;45(4):493-6 PMID: 5325707
Properties of a cryptic high-frequency transducing phage in Staphylococcus aureus.
Virology. 1967 Sep;33(1):155-66 PMID: 4227577
Mechanisms of antibiotic resistance in bacteria.
Annu Rev Biochem. 1973;42:471-506 PMID: 4581231
Enzymes that inactivate antibiotics in transit to their targets.
Ann N Y Acad Sci. 1974 May 10;235(0):130-6 PMID: 4527785
Evolution of plasmids in vivo in a strain of Staphylococcus aureus.
J Med Microbiol. 1974 Feb;7(1):117-25 PMID: 4496491
Aminoglycoside-modifying enzymes.
Methods Enzymol. 1975;43:611-28 PMID: 166284
Enzymatic modification of aminoglycoside antibiotics: a new 3-N-acetylating enzyme from a Pseudomonas aeruginosa isolate.
Antimicrob Agents Chemother. 1976 Jun;9(6):951-5 PMID: 820250

Article Info

Journal

Antimicrobial agents and chemotherapy

Abbr.

Antimicrob Agents Chemother

ISSN

0066-4804

DOI

10.1128/AAC.11.4.619

Published

1977-04-00

Pages

619-24

Language

English

Region

United States

NLM ID

0315061

PMCID

PMC352039

Subset

External Links

PubMed source DOI: 10.1128/AAC.11.4.619 PMC Full Text View journal details

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Plasmid-medicated aminoglycoside phosphotransferase of broad substrate range that phosphorylates amikacin.

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