Home LiteratureArticle Details
PMID: 4157356 Published · ppublish English Journal Article

Isolation and characterization of a kanamycin resistance plasmid from Staphylococcus aureus.

Antimicrobial agents and chemotherapy ·Vol. 6 ·No. 4 ·1974-10-00 ·Pages 516-20

Stiffler PW, Sweeney HM, Schneider M, Cohen S

Abstract

A circular covalently closed duplex deoxyribonucleic acid plasmid carrying genes for resistance to kanamycin/neomycin has been identified in Staphylococcus aureus E419. The plasmid has a molecular size of 9.2 x 10(6) daltons and can be transduced into or can transform competent susceptible strains of S. aureus to kanamycin/neomycin resistance.

MeSH Terms
DNA, Circular Kanamycin Resistance/genetics Molecular Weight Plasmids Staphylococcus aureus/genetics Transformation, Genetic
Chemicals
DNA, Circular
Authors & Affiliations
4 authors, click to expand affiliations / ORCID
Stiffler P W
Sweeney H M
Schneider M
Cohen S
References (24)
24 references, click to expand
  1. Physical and topological properties of circular DNA.
    J Gen Physiol. 1966 Jul;49(6):103-25 PMID: 4290891
  2. Supercoiled circular DNA-protein complex in Escherichia coli: purification and induced conversion to an opern circular DNA form.
    Proc Natl Acad Sci U S A. 1969 Apr;62(4):1159-66 PMID: 4894690
  3. Simplified quantitative electron microscopy of biopolymers.
    Biopolymers. 1970;9(3):373-9 PMID: 5417647
  4. [VARIATIONS UNDER THE INFLUENCE OF ACRIFLAVIN AND TRANSDUCTION OF RESISTANCE TO KANAMYCIN AND CHLORAMPHENICOL IN STAPHYLOCOCCI].
    Ann Inst Pasteur (Paris). 1964 Nov;107:678-90 PMID: 14229536
  5. Genetic basis, epidemiology, and future significance of antibiotic resistance in Staphylococcus aureus: a review.
    J Clin Pathol. 1973 Dec;26(12):899-913 PMID: 4593862
  6. Transduction of Methicillin Resistance in Staphylococcus aureus Dependent on an Unusual Specificity of the Recipient Strain.
    J Bacteriol. 1970 Dec;104(3):1158-67 PMID: 16559089
  7. Inactivation and phosphorylation of kanamycin by drug-resistant Staphylococcus aureus.
    Appl Microbiol. 1968 Sep;16(9):1282-4 PMID: 5676403
  8. High-frequency transfer of neomycin resistance between naturally occurring strains of Staphylococcus aureus.
    J Med Microbiol. 1971 Feb;4(1):73-84 PMID: 4251340
  9. Naturally occurring penicillinase plasmids in Staphylococcus aureus.
    J Bacteriol. 1969 Apr;98(1):215-21 PMID: 5781577
  10. Sedimentation rate as a measure of molecular weight of DNA.
    Biophys J. 1963 Jul;3:309-21 PMID: 14016998
  11. Mechanisms of antibiotic resistance in bacteria.
    Annu Rev Biochem. 1973;42:471-506 PMID: 4581231
  12. Nonchromosomal antibiotic resistance in bacteria: genetic transformation of Escherichia coli by R-factor DNA.
    Proc Natl Acad Sci U S A. 1972 Aug;69(8):2110-4 PMID: 4559594
  13. Antibiotic susceptibility testing by a standardized single disk method.
    Am J Clin Pathol. 1966 Apr;45(4):493-6 PMID: 5325707
  14. Circular DNA forms of colicinogenic factors E1, E2 and E3 from Escherichia coli.
    J Mol Biol. 1968 Sep 14;36(2):185-94 PMID: 4939624
  15. Characterization of multiple circular DNA forms of colicinogenic factor E-1 from Proteus mirabilis.
    Biochemistry. 1968 Oct;7(10):3513-20 PMID: 4878700
  16. The problems of drug-resistant pathogenic bacteria. Extrachromosomal nature of drug resistance in Staphylococcus aureus.
    Ann N Y Acad Sci. 1971 Jun 11;182:279-94 PMID: 5285292
  17. Properties of a cryptic high-frequency transducing phage in Staphylococcus aureus.
    Virology. 1967 Sep;33(1):155-66 PMID: 4227577
  18. Transduction of chromosomal genes and episomes in Escherichia coli.
    Virology. 1960 May;11:273-88 PMID: 13794037
  19. A variety of Staphylococcal plasmids present as multiple copies.
    J Gen Microbiol. 1973 Dec;79(2):343-5 PMID: 4772094
  20. Unstable resistance to kanamycin, lincomycin and penicillin in a methicillin resistant culture of Staphylococcus aureus.
    Pathology. 1972 Oct;4(4):247-52 PMID: 4485568
  21. Absence of circular plasmid deoxyribonucleic acid attributable to a genetic determinant for methicillin resistance in Staphylococcus aureus.
    J Bacteriol. 1973 Nov;116(2):771-7 PMID: 4490525
  22. ANALYSIS BY TRANSDUCTION OF MUTATIONS AFFECTING PENICILLINASE FORMATION IN STAPHYLOCOCCUS AUREUS.
    J Gen Microbiol. 1963 Oct;33:121-36 PMID: 14072829
  23. Plasmid-specific transformation in Staphylococcus aureus.
    J Bacteriol. 1973 Jul;115(1):139-45 PMID: 4717511
  24. Molecular structure of bacterial plasmids.
    Bacteriol Rev. 1972 Sep;36(3):361-405 PMID: 4345849
Article Info
Journal
Antimicrobial agents and chemotherapy
Abbr.
Antimicrob Agents Chemother
ISSN
0066-4804
DOI
10.1128/AAC.6.4.516
Published
1974-10-00
Pages
516-20
Language
English
Region
United States
NLM ID
0315061
PMCID
PMC444682
Subset
IM
External Links
PubMed source DOI: 10.1128/AAC.6.4.516 PMC Full Text View journal details
Analysis Services
Analysis Services

Contact

No. 2 Wenbo Road, Zhangqiu District, Jinan, Shandong

Qilu Normal University · Genelibs Bioinformatics Lab

750 Shunhua Rd, Jinan

2F, Bldg F, University Science Park

Tel: 0531-88819269

WeChat Official Account

Follow our WeChat subscription account for real-time updates and the latest in medical and biological research.


Business Email

E-mail: product@genelibs.com

Copyright © 2026.Genelibs Jinan Honghui Biotechnology Co., Ltd. 鲁ICP备20007159号-2