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PMID: 8550529 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't

Negative regulation by fliD, fliS, and fliT of the export of the flagellum-specific anti-sigma factor, FlgM, in Salmonella typhimurium.

Journal of bacteriology ·Vol. 178 ·No. 3 ·1996-02-00 ·Pages 899-901

Yokoseki T, Iino T, Kutsukake K

Abstract

The fliD operon of Salmonella typhimurium consists of three flagellar genes, fliD, fliS, and fliT, and is transcribed in this order. It has been shown that an fliD::Tn10 mutation causes an excess export of the flagellum-specific anti-sigma factor, FlgM, resulting in an overexpression of flagellar class 3 operons. In this study, using gene-disruption mutants in the individual genes in the fliD operon, we showed that mutations in any one of the genes in the operon enhanced both FlgM export and the expression of flagellar regulon. This indicates that all three genes in the operon are involved in the negative regulation of FlgM export.

MeSH Terms
Bacterial Proteins/metabolism,physiology Flagella/physiology Molecular Chaperones Mutation Operon Salmonella typhimurium/physiology Sigma Factor/antagonists & inhibitors
Chemicals
Bacterial Proteins Molecular Chaperones Sigma Factor FlgM protein, Bacteria FlaD protein, Bacteria FliS protein, Bacteria fliT protein, Bacteria
Authors & Affiliations
3 authors, click to expand affiliations / ORCID
Yokoseki T
Faculty of Applied Biological Science, Hiroshima University, Japan.
Iino T
Kutsukake K
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21 references, click to expand
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Article Info
Journal
Journal of bacteriology
Abbr.
J Bacteriol
ISSN
0021-9193
DOI
10.1128/jb.178.3.899-901.1996
Published
1996-02-00
Pages
899-901
Language
English
Region
United States
NLM ID
2985120R
PMCID
PMC177741
Subset
IM
External Links
PubMed source DOI: 10.1128/jb.178.3.899-901.1996 PMC Full Text View journal details
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