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PMID: 8519476 Published · ppublish English Journal Article Research Support, Non-U.S. Gov't Review

Genetic analysis of adherence by oral streptococci.

Journal of industrial microbiology ·Vol. 15 ·No. 3 ·1995-09-00 ·Pages 186-92

Jenkinson HF

Abstract

Streptococci are one of the most successful bacterial colonizers of the human body and are major components of oral biofilms. The bacterial cells express multiple cell-surface adhesins that are responsible for the ability of streptococci to adhere to a wide range of substrates which include salivary and serous proteins, epithelial cells and other bacterial cells. Analysis of adherence-defective mutants has indicated the importance of high molecular mass wall-associated polypeptides and of enzymes catalyzing extracellular glucan polysaccharide synthesis to the adherence and accumulation of oral streptococci. The analysis of isogenic mutants of streptococci, generated through insertional inactivation (or allelic exchange), has confirmed the essential roles of specific surface polypeptides both to adhesive processes and to correct assembly of the cell wall layers.

MeSH Terms
Bacterial Adhesion/genetics Biofilms/growth & development Genes, Bacterial Humans Molecular Biology Mouth/microbiology Mutation Phenotype Streptococcus/genetics,physiology
Authors & Affiliations
1 authors, click to expand affiliations / ORCID
Jenkinson H F
Department of Oral Biology and Oral Pathology, University of Otago, Dunedin, New Zealand.
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Article Info
Journal
Journal of industrial microbiology
Abbr.
J Ind Microbiol
ISSN
0169-4146
DOI
10.1007/BF01569824
Published
1995-09-00
Pages
186-92
Language
English
Region
England
NLM ID
8610887
External Links
PubMed source DOI: 10.1007/BF01569824
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